Protein Info for LRK53_RS12045 in Rhodanobacter sp000427505 FW510-R12

Annotation: cation:proton antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 588 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 31 to 50 (20 residues), see Phobius details amino acids 60 to 77 (18 residues), see Phobius details amino acids 85 to 110 (26 residues), see Phobius details amino acids 118 to 137 (20 residues), see Phobius details amino acids 149 to 174 (26 residues), see Phobius details amino acids 183 to 208 (26 residues), see Phobius details amino acids 220 to 253 (34 residues), see Phobius details amino acids 272 to 291 (20 residues), see Phobius details amino acids 297 to 319 (23 residues), see Phobius details amino acids 331 to 350 (20 residues), see Phobius details amino acids 356 to 375 (20 residues), see Phobius details amino acids 424 to 445 (22 residues), see Phobius details amino acids 465 to 483 (19 residues), see Phobius details amino acids 515 to 537 (23 residues), see Phobius details amino acids 543 to 562 (20 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 15 to 373 (359 residues), 197.2 bits, see alignment E=2e-62

Best Hits

KEGG orthology group: K03455, monovalent cation:H+ antiporter-2, CPA2 family (inferred from 50% identity to ppw:PputW619_5133)

Predicted SEED Role

"POTASSIUM/PROTON ANTIPORTER ROSB" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (588 amino acids)

>LRK53_RS12045 cation:proton antiporter (Rhodanobacter sp000427505 FW510-R12)
MHEIGFIRDLAVVMIVAGATTILFQRMRQPVLLGYILAGVLIGPHTPGVLVGDPRAIDDI
SNLGVVLLMFTLGLEFSVRKLREVGVGVLVAAVAEVGLMLWIGYGIGGLFGWSGKDALFL
GAIISLSSTMVATRTLAEGGQRQQPFAQLVIGLLVAEDMLAIVMLTLLTAVAIGGSVEAE
TAFALVGHLGLFVIVGMILGLLLLPRLVDYVAGFDRDETLLVSVLGICFGASLFAAWMGF
SVALGAFLAGAVVAESRSVGRVLHLVEPLRDMFAALFFVAIGLKIDPAMLLQYALPALLI
AVAVIVGKTLTCSLGVFMVGHEPRTALRAGLGMAQIGEFSFVIATLGLSLGVISDFIYPI
AVAVSVLCMAASPYLSRSADGLADGLRRLTPRSLRLLATSYSGWLENLKPVDENAAIAAM
FRRLLWHIGINVLLVVALFVIGAYVNAHNWSWFSMLGIDRELRHTLIWAAALFLSLPMLI
AVYRKAGALGMLLAEIGIRERFAGAYTQAIRNVLARVIPLATLLALALLVSALSSAILPP
RGIALSLLVLGVLAAVVLWRGLVKMHARLQAALKETLEKPAPPGDGAG