Protein Info for LRK53_RS11995 in Rhodanobacter sp000427505 FW510-R12

Annotation: Do family serine endopeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 490 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details TIGR02037: peptidase Do" amino acids 35 to 482 (448 residues), 476.1 bits, see alignment E=5.6e-147 PF00089: Trypsin" amino acids 103 to 256 (154 residues), 72.2 bits, see alignment E=1.8e-23 PF13365: Trypsin_2" amino acids 105 to 241 (137 residues), 134.2 bits, see alignment E=1.8e-42 PF00595: PDZ" amino acids 276 to 358 (83 residues), 29.7 bits, see alignment E=2e-10 amino acids 391 to 473 (83 residues), 36.3 bits, see alignment E=1.8e-12 PF13180: PDZ_2" amino acids 280 to 371 (92 residues), 59.8 bits, see alignment E=7.8e-20 amino acids 397 to 479 (83 residues), 38.7 bits, see alignment E=2.9e-13 PF17820: PDZ_6" amino acids 307 to 360 (54 residues), 29.9 bits, see alignment 1.1e-10 amino acids 427 to 475 (49 residues), 39 bits, see alignment 1.6e-13

Best Hits

Swiss-Prot: 50% identical to DEGPL_PSEPW: Probable periplasmic serine endoprotease DegP-like (PputW619_1070) from Pseudomonas putida (strain W619)

KEGG orthology group: None (inferred from 48% identity to pfs:PFLU1471)

Predicted SEED Role

"HtrA protease/chaperone protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (490 amino acids)

>LRK53_RS11995 Do family serine endopeptidase (Rhodanobacter sp000427505 FW510-R12)
MSHSILRSLACFALLGIASAGTVQAQAPAAAALPDFTGIVQKNAPAVVHVEARYNGERQG
NSRSMHGQTMPGQGMPDDPQAEILRRFFGMPMMPSPQEQKHISLGSGFIISGDGYILTNN
HVVDHADKVTVRLQDRRTLTAKVIGTDPTYDIALLKVDAGGSLPAVTLGDSRSLKPGQWV
LAIGSPFGFDYTVTQGIVSAVGRNLGQRDQPYTSFIQTDVPINRGNSGGPLFDLQGRVVG
INSQIYSNTGTYSGVAFSIPIDVAMNAVQQLKSKGYVSRGMLGVTVQPVDDDMVKAFGLD
NGVGAAVVDVTAGSGAAKAGIQSGDVILAYDGRTLQQAPDLPPLVGMTKPGSKVPVEILR
NGKKQTLQVTVGEASRDRNAMNGQGTAPSLARSGSAVLGLTVQSIDDDTRTQLGLKPGQG
VVIGDITGSVAAQAGLQTGDVILMVNQQKVGSVAEFEAATKGVKAGSTVLLLVRRGEQSS
FIGLTVPDGE