Protein Info for LRK53_RS11065 in Rhodanobacter sp000427505 FW510-R12

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 818 transmembrane" amino acids 170 to 190 (21 residues), see Phobius details amino acids 202 to 224 (23 residues), see Phobius details amino acids 235 to 255 (21 residues), see Phobius details amino acids 261 to 278 (18 residues), see Phobius details amino acids 415 to 434 (20 residues), see Phobius details amino acids 440 to 462 (23 residues), see Phobius details amino acids 752 to 773 (22 residues), see Phobius details amino acids 779 to 798 (20 residues), see Phobius details PF00403: HMA" amino acids 43 to 101 (59 residues), 46.2 bits, see alignment 9.9e-16 TIGR01511: copper-translocating P-type ATPase" amino acids 216 to 799 (584 residues), 604.6 bits, see alignment E=4e-185 TIGR01525: heavy metal translocating P-type ATPase" amino acids 234 to 798 (565 residues), 606.9 bits, see alignment E=8.8e-186 TIGR01494: HAD ATPase, P-type, family IC" amino acids 268 to 784 (517 residues), 302.4 bits, see alignment E=9.3e-94 PF00122: E1-E2_ATPase" amino acids 295 to 476 (182 residues), 188.2 bits, see alignment E=2e-59 PF00702: Hydrolase" amino acids 493 to 705 (213 residues), 134 bits, see alignment E=1.8e-42

Best Hits

KEGG orthology group: None (inferred from 63% identity to adk:Alide2_2732)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (818 amino acids)

>LRK53_RS11065 heavy metal translocating P-type ATPase (Rhodanobacter sp000427505 FW510-R12)
MTGQDPGQRGSAGDLHALVGPVEASTHTMDAHAPSSRSHAWPIGGMVSAGCARTLEQTIA
QLPGVRAADASFAASRLKVDYDPAQVDASRIAEAIRRCGFECATNGHRDVAHAHDGHAHA
HHHAHADETGREQPAAGSHADHAADAGDAHAGMHHGGDLHAAARDMRRRFLVALAFAIPV
FLWSPMGLMQPLPVPFGLDKNVWLFLLASGAVLYPGWPFFTAAIRSLRHGVLDMSVLVLL
SVGTGYGFSIASTFFFEGPNFYEASAVLLTFILLGHWLEMRARAGASDAMRALLKLSPPR
AIVRRDGQDLEVATAEVRAGDVVVVRPGAKVPVDGTVLEGSSQVDESMLTGESMPVRKDP
GATVVGGSINKSGAFAYTATKVGGDTALAQIIKLVQDAQNSKAPAQLLADRASQWLVLAA
IVIGVATFVVWYWWLDQSLLFALTLTITVFVIACPDALGLATPMAIMIGTGLGARHGILF
KHAEAIELSARLDVVIFDKTGTLTVGQPEVVDLATAPGWTPERLLAAAAAVEVHSEHPLA
QAILKRAGAVPTRATAFTNIDGQGATGVVDGAQVLLGNRLLMAEHGVDLGGLEADAARLT
GAGRTVIFVGVDGQLAGLIAIADAIRESSRAAIEELHRRNVKVAMITGDNRPTAERVARD
LGIDIVLADVLPAGKADEVRKLQAQGQKVGMVGDGVNDAPALTQAEVGFAIGAGTDVAIE
SADIVLMRSDPYDVVRAVTIARATLRKMHQNLAWAVGYNVVAFPLAAGVLYPFTLSPEIA
ALSMSGSSVIVAVNALMLRRVRLAPRSGDTSPSQKAAT