Protein Info for LRK53_RS10495 in Rhodanobacter sp000427505 FW510-R12

Annotation: EAL domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 561 PF00563: EAL" amino acids 214 to 445 (232 residues), 147.3 bits, see alignment E=2.5e-47

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (561 amino acids)

>LRK53_RS10495 EAL domain-containing protein (Rhodanobacter sp000427505 FW510-R12)
MKKVDGKATVRSVRQGARAGQFARNDVLLRISAIAWSADCYPDFIQRVAATLLTLDEIVG
CAIGRPDAYGRFHFEAVAGSEAFIGCLRAVERGEHPDIRAEAQRLGGSMAMGRAWQSGGI
QRTFNYATDPEMTVWRGVALGLGIRSNAAIPVRLPKGTTESVLTLYSSATGGFSTASQHT
FLLHLQSLLGLALTRLLPKTEGIQAAPLLLRDHWRAKLATDDLVMQYQPVVDLRMGKVVE
VEALARIREDDHLILPIWFLPALGSDDLLFLYQQGLTQALAARQQWATDGLALGIAVNLP
SSALLDRRYVDITREVLEQHPCPSGTLVLELLESEWMDETIDAESGLLALKALGIQLAED
DLGLAYSSLSRLRHLSFDRIKIDQTLVAQIARQPLRTLYFIYQLTRLGHDLGVKVVVEGL
ETAGLIEAATILGADLGQGFALARPMSGAHVADWCVSSRFACDPMVPRTALGALSGFLLW
EDRLGMFMDDTAMIATLVRTSCRVDAYLHASAAKGTQLDRIHRLLHQIAIRQGPASASYT
KARNAFIECLVEDWIRIEENG