Protein Info for LRK53_RS08340 in Rhodanobacter sp000427505 FW510-R12

Annotation: phosphoribosylanthranilate isomerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 53% identical to TRPF_PSEU5: N-(5'-phosphoribosyl)anthranilate isomerase (trpF) from Pseudomonas stutzeri (strain A1501)

KEGG orthology group: K01817, phosphoribosylanthranilate isomerase [EC: 5.3.1.24] (inferred from 56% identity to tgr:Tgr7_1252)

Predicted SEED Role

"Phosphoribosylanthranilate isomerase (EC 5.3.1.24)" in subsystem Auxin biosynthesis or Tryptophan synthesis (EC 5.3.1.24)

MetaCyc Pathways

superpathway of aromatic amino acid biosynthesis (18/18 steps found)
superpathway of L-tryptophan biosynthesis (13/13 steps found)
L-tryptophan biosynthesis (6/6 steps found)
superpathway of chorismate metabolism (39/59 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.3.1.24

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (207 amino acids)

>LRK53_RS08340 phosphoribosylanthranilate isomerase (Rhodanobacter sp000427505 FW510-R12)
MTRIKCCGMTRVGDALLAARLGADAIGLVFTARSRRQVTLAQAREIVAALPPFVATVALF
MDDEAALVQQVLDAVRPTWLQFHGSESDAWCAQFGHPFLKAVAMGEGATALSRLQAYPHA
AGLLLDGHAAGEAGGSGRTFDWSLLPDSLAQPLILAGGLHAGNVGEAVRTARPWAVDVAS
GVESAPGIKDPARLEAFIRAVREADTA