Protein Info for LRK53_RS06565 in Rhodanobacter sp000427505 FW510-R12

Annotation: metalloprotease TldD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 479 PF01523: PmbA_TldD_1st" amino acids 38 to 102 (65 residues), 56.1 bits, see alignment E=5.3e-19 PF19290: PmbA_TldD_2nd" amino acids 126 to 235 (110 residues), 85.5 bits, see alignment E=5.2e-28 PF19289: PmbA_TldD_3rd" amino acids 243 to 476 (234 residues), 239.2 bits, see alignment E=4.8e-75

Best Hits

KEGG orthology group: K03568, TldD protein (inferred from 73% identity to smt:Smal_2898)

Predicted SEED Role

"TldD protein, part of TldE/TldD proteolytic complex"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (479 amino acids)

>LRK53_RS06565 metalloprotease TldD (Rhodanobacter sp000427505 FW510-R12)
MDSLITLAESKLLAPGGLATGDLDRVFGQLMGPAIDAADLYFQHSRSESWTLEEGIVKDG
SHSIEQGVGVRAISGEKTGFAYSDEIVLPQLLEASKAARAIARDGQGAGQPLALHGARAL
YPAIDPVESLPNPDKIALLREVDAYARSRDPRIKQVIVSLAATIDTVLIAASDGTLAADV
RPLVRINVQVIAEANGRREQGYSGGGGRYGYRELIENGRALRFADEAVRQALVNLDSVDA
PAGQMTVVLGPGWPGVLLHEAIGHGLEGDFNRKGSSAFSGRIGQRVAAKGVTIVDDGTLA
GRRGSLSIDDEGTPTECTTLIEDGILKGYMQDKLNARLMGMAPTGNGRRESFTALPMPRM
TNTYMRAGQHDPAEIIRSVKKGLYAPNFGGGQVDITNGKFTFSASEAYLIEDGRITRPVK
GATLIGSGPDVLNRVSMIGNDLALDEGVGVCGKDGQSVPVGVGQPTLKIDSMTVGGTAS