Protein Info for LRK53_RS01780 in Rhodanobacter sp000427505 FW510-R12

Annotation: sodium-translocating pyrophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 690 transmembrane" amino acids 6 to 29 (24 residues), see Phobius details amino acids 57 to 75 (19 residues), see Phobius details amino acids 81 to 102 (22 residues), see Phobius details amino acids 122 to 147 (26 residues), see Phobius details amino acids 159 to 177 (19 residues), see Phobius details amino acids 232 to 251 (20 residues), see Phobius details amino acids 257 to 278 (22 residues), see Phobius details amino acids 290 to 309 (20 residues), see Phobius details amino acids 329 to 348 (20 residues), see Phobius details amino acids 375 to 400 (26 residues), see Phobius details amino acids 405 to 425 (21 residues), see Phobius details amino acids 468 to 485 (18 residues), see Phobius details amino acids 514 to 533 (20 residues), see Phobius details amino acids 583 to 602 (20 residues), see Phobius details amino acids 608 to 629 (22 residues), see Phobius details TIGR01104: V-type H(+)-translocating pyrophosphatase" amino acids 9 to 690 (682 residues), 908.1 bits, see alignment E=2.4e-277 PF03030: H_PPase" amino acids 15 to 686 (672 residues), 912.4 bits, see alignment E=9.3e-279

Best Hits

Swiss-Prot: 62% identical to HPPA_CAUVC: K(+)-insensitive pyrophosphate-energized proton pump (hppA) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

Predicted SEED Role

"Pyrophosphate-energized proton pump (EC 3.6.1.1)" in subsystem Phosphate metabolism (EC 3.6.1.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.1

Use Curated BLAST to search for 3.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (690 amino acids)

>LRK53_RS01780 sodium-translocating pyrophosphatase (Rhodanobacter sp000427505 FW510-R12)
MLQQYGWWIVVACAVVAVLYGALSARWILAKSPGNERMQEIAAAIQEGARAYLNRQYTTI
GLVGVVLLLLIGFFLTWPTAIGFLLGAVLSGAAGYIGMNVSVRANVRTAEAARSGLGAAM
DVAFRGGAITGMLVVGLALLGVAGYWLVLGHFGVTGEAALHALVGLAFGSSLISIFARLG
GGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETYAVTVI
ATMLLAGLSFADNLAAVMYPLVLGGVSIIASIIATFFVRVKAGGSIMGALYKGVIVSAVL
SAVAFWFVTGNLLPQGLTAADGSVVSSHALFYCALIGLVLTGLIVWITEYYTGTQYGPVQ
HIAAASTTGHGTNIIAGLGVSMKSTAMPVIVICAAIWGAYSLGGLYGIAIAATAMLSMAG
MIVALDAYGPITDNAGGIAEMADLPPEVRGVTDPLDAVGNTTKAVTKGYAIGSAALAALV
LFADYTHNLDVAAQAKAAAAGSTYTPLTFDLSDHMVIIGLLIGGLIPYLFGAMAMEAVGR
AAGAVVEEVRRQFRDIAGIMQGTGKPEYSRAVDMLTRSAIREMIVPSLLPVAVPIVVGLL
LGPKALGGVLIGTIVTGLFVAISMTTGGGAWDNAKKYIEDGHHGGKGSEAHKAAVTGDTV
GDPYKDTAGPAVNPLIKIINIVALLMIPLL