Protein Info for LRK53_RS01630 in Rhodanobacter sp000427505 FW510-R12

Annotation: protein-disulfide reductase DsbD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 729 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 331 to 355 (25 residues), see Phobius details amino acids 376 to 399 (24 residues), see Phobius details amino acids 414 to 437 (24 residues), see Phobius details amino acids 457 to 483 (27 residues), see Phobius details amino acids 490 to 515 (26 residues), see Phobius details amino acids 531 to 548 (18 residues), see Phobius details amino acids 555 to 573 (19 residues), see Phobius details amino acids 585 to 602 (18 residues), see Phobius details PF11412: DsbD_N" amino acids 34 to 149 (116 residues), 92.7 bits, see alignment E=2.6e-30 amino acids 187 to 301 (115 residues), 97.4 bits, see alignment E=9e-32 PF02683: DsbD_TM" amino acids 332 to 544 (213 residues), 70.8 bits, see alignment E=1.6e-23 PF13899: Thioredoxin_7" amino acids 620 to 702 (83 residues), 54.9 bits, see alignment E=1.2e-18

Best Hits

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.8

Use Curated BLAST to search for 1.8.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (729 amino acids)

>LRK53_RS01630 protein-disulfide reductase DsbD (Rhodanobacter sp000427505 FW510-R12)
MRLISGRLAARLPALALLLLGLLCTAPAPAQDTESLLPVTEAYKLSADTSTPGVLKLHWT
IAPDYYLYRGRMKFKGGDGVTLGEAQLPDGRKDHDEYLGDVETYRHGVDASIPYTVAAGT
TRLTLSVQYQGCHEVDPKICYPPHTEKLDLPLPANAGVAATPAAGNALGAALSRLGSSTG
TTAVGAPLPTEQAFHFEALAQGPKHLLLRWTMPKGYYLYRDQTALKLADAAGLTLTPAWP
PGVAHRDEHYGEVIVYFDQVELPVTVEGDLAGRTHLALQASFQGCQDGGLCYPLMTRTVD
IELNSGAATAGTPAPELPPADLVGGPLQVSLLAALLLALGGGLVLNLMPCVLPVLSIKAV
SVLESGENRATARRHALFYTAGVLCSFAALGLGILALRAAGHALGWGSQLQQPLLVGVLA
CVMLAVGLSMSGVVQFGASLGNTGASLASRSGPAGDFFTGVLAVVVASPCTAPFMGSALA
YAFAAPMLSALLVFIVLGVGLALPFLAVGFVPALARLLPKPGRWMETLKQVLAFPMFLTA
AWLVWVLANQRGADAVGLVLVAMVLLAMTLWWFERSRSRGAASKVAVVMLALATLAPLYL
LAHVPPPSAAATAEQGVVAYSPQKLTELRAAGTPVFVDITADWCVTCKANEHAVLNTQAF
RNLLRRTDTVYMKGDWTDVNPAISAFLQEYHSPGVPLYVVFPKNLGPGRQLPTVLTYSMV
EQALTEATR