Protein Info for LRK53_RS00025 in Rhodanobacter sp000427505 FW510-R12

Annotation: tetratricopeptide repeat protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 421 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details PF09976: TPR_21" amino acids 58 to 191 (134 residues), 25.6 bits, see alignment E=3.7e-09 PF13432: TPR_16" amino acids 344 to 403 (60 residues), 22.4 bits, see alignment E=5.4e-08

Best Hits

Predicted SEED Role

"TPR domain protein, putative component of TonB system" in subsystem Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (421 amino acids)

>LRK53_RS00025 tetratricopeptide repeat protein (Rhodanobacter sp000427505 FW510-R12)
MLAGVALLLGVASSPALARKSDDATPKKEALYPNATRTEPKLDLSSAKDQKSLNDGLDAV
NEGDKAKAEQLLQPIIDGSKSKYAQALALQGMASLHYNDGDIKGAISTLQRSLALGVMPN
DTYFQLMYMLAQFQLADEQYQPALDTVAKWRAEGKKETADSYALEGNAYYRLNKYPEAIA
AITKAKSLTDKPQPTWDQILMASYSESGQDDKAAQLATSQLNSNPSDPNALNNAVAVLMQ
AHKYPEAIQMLEKARAAGTLTKDTQYVNLAKLYLIAGQESSDPTPNALKAQQVLEDGIGK
GIVKPDAGTYVLLGQAAEIGNNADKAISYYNKAIPLASDGEAALAAGRLLLSENKYSQAK
GLVQQAIDKGVKHKGTAYMLLAESERGLKNKPAAIAAMKNAAKDPETAAKARDWLKKTGA
E