Protein Info for JDDGAC_16105 in Escherichia coli ECRC98

Name: cadB
Annotation: cadaverine/lysine antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 444 transmembrane" amino acids 7 to 27 (21 residues), see Phobius details amino acids 36 to 58 (23 residues), see Phobius details amino acids 94 to 114 (21 residues), see Phobius details amino acids 121 to 139 (19 residues), see Phobius details amino acids 149 to 169 (21 residues), see Phobius details amino acids 189 to 208 (20 residues), see Phobius details amino acids 220 to 241 (22 residues), see Phobius details amino acids 268 to 290 (23 residues), see Phobius details amino acids 323 to 344 (22 residues), see Phobius details amino acids 350 to 371 (22 residues), see Phobius details amino acids 383 to 401 (19 residues), see Phobius details amino acids 407 to 425 (19 residues), see Phobius details TIGR00905: transporter, basic amino acid/polyamine antiporter (APA) family" amino acids 2 to 443 (442 residues), 488.5 bits, see alignment E=1.1e-150 PF13520: AA_permease_2" amino acids 7 to 418 (412 residues), 144.8 bits, see alignment E=3.8e-46 PF00324: AA_permease" amino acids 18 to 377 (360 residues), 75.3 bits, see alignment E=4.3e-25

Best Hits

Swiss-Prot: 100% identical to CADB_ECOL6: Probable cadaverine/lysine antiporter (cadB) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K03757, cadaverine:lysine antiporter (inferred from 100% identity to eco:b4132)

MetaCyc: 100% identical to lysine:cadaverine antiporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-68; TRANS-RXN0-212

Predicted SEED Role

"Lysine/cadaverine antiporter membrane protein CadB" in subsystem Lysine degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (444 amino acids)

>JDDGAC_16105 cadaverine/lysine antiporter (Escherichia coli ECRC98)
MSSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWIISIIGAMSLAYVYARL
ATKNPQQGGPIAYAGEISPAFGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPVLNDPVP
AGIACIAIVWVFTFVNMLGGTWVSRLTTIGLVLVLIPVVMTAIVGWHWFDAATYAANWNT
ADTTDGHAIIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTGLAGIVYIAATQ
VLSGMYPSSVMAASGAPFAISASTILGNWAAPLVSAFTAFACLTSLGSWMMLVGQAGVRA
ANDGNFPKVYGEVDSNGIPKKGLLLAAVKMTALMILITLMNSAGGKASDLFGELTGIAVL
LTMLPYFYSCVDLIRFEGVNIRNFVSLICSVLGCVFCFIALMGASSFELAGTFIVSLIIL
MFYARKMHERQSHSMDNHTASNAH