Protein Info for IAI46_18985 in Serratia liquefaciens MT49

Annotation: MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 476 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 49 to 70 (22 residues), see Phobius details amino acids 77 to 97 (21 residues), see Phobius details amino acids 103 to 124 (22 residues), see Phobius details amino acids 134 to 158 (25 residues), see Phobius details amino acids 164 to 186 (23 residues), see Phobius details amino acids 198 to 215 (18 residues), see Phobius details amino acids 227 to 245 (19 residues), see Phobius details amino acids 266 to 285 (20 residues), see Phobius details amino acids 295 to 314 (20 residues), see Phobius details amino acids 327 to 347 (21 residues), see Phobius details amino acids 353 to 373 (21 residues), see Phobius details amino acids 394 to 417 (24 residues), see Phobius details amino acids 432 to 452 (21 residues), see Phobius details PF07690: MFS_1" amino acids 16 to 406 (391 residues), 163.6 bits, see alignment E=6.4e-52 TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 17 to 426 (410 residues), 236.1 bits, see alignment E=3.6e-74 PF05977: MFS_3" amino acids 35 to 172 (138 residues), 29 bits, see alignment E=3.9e-11

Best Hits

Swiss-Prot: 98% identical to MDTD_SERP5: Putative multidrug resistance protein MdtD (mdtD) from Serratia proteamaculans (strain 568)

KEGG orthology group: None (inferred from 98% identity to spe:Spro_3555)

Predicted SEED Role

"Multidrug transporter MdtD"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (476 amino acids)

>IAI46_18985 MFS transporter (Serratia liquefaciens MT49)
MLIKHTASVQWQLWIVAFGFFMQTLDTTIVNTALPSMAVSLGENPLRMQSVIVSYVLTVA
VMLPASGWLADRFGVQRVFFSAIVLFTLGSILCARSETLNELIASRVIQGIGGAMMVPVG
RLTVMKIVPREQYMAAMTFVTLPGQIGPLMGPALGGFLVQYASWHWIFLINIPVGIAGAI
ATLLLMPNYRMQTRRFDISGFIMLAIGMATLTLALDGHKGMGLSSPAIAALVVVGIAALA
GYWWHAHGNSRALFSLRLFKTQTYKVGLTASLLGRIGSGMLPFMTPLFMQVGMGFSPFHA
GLMMIPMIIGSMGMKRIVVRVVNRFGYRNVLVAATLMLALISLSFPLVAMLGWIWLLPVV
LFFQGMVNSLRFSAMNTLTLKDLPDRLASSGNSLLSMVMQLSMSLGVSIAGILIGSFAHH
QVVTDSPAIHSAFIYSYCCMALIIALPALAFARVPADTAPNRTLTKEPGTGSTRLQ