Protein Info for IAI46_13470 in Serratia liquefaciens MT49

Annotation: transcriptional regulator TyrR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 523 TIGR00229: PAS domain S-box protein" amino acids 78 to 129 (52 residues), 29.8 bits, see alignment 5.5e-11 PF13188: PAS_8" amino acids 82 to 123 (42 residues), 33.2 bits, see alignment 9.2e-12 PF00989: PAS" amino acids 82 to 169 (88 residues), 34.1 bits, see alignment E=6.2e-12 PF00158: Sigma54_activat" amino acids 206 to 372 (167 residues), 213.8 bits, see alignment E=3.3e-67 PF14532: Sigma54_activ_2" amino acids 207 to 377 (171 residues), 70.7 bits, see alignment E=3.9e-23 PF18024: HTH_50" amino acids 465 to 513 (49 residues), 66.5 bits, see alignment 3.3e-22 TIGR04381: TyrR family helix-turn-helix domain" amino acids 466 to 513 (48 residues), 93.7 bits, see alignment 5e-31

Best Hits

Swiss-Prot: 77% identical to TYRR_ENTAG: Transcriptional regulatory protein TyrR (tyrR) from Enterobacter agglomerans

KEGG orthology group: K03721, transcriptional regulator of aroF, aroG, tyrA and aromatic amino acid transport (inferred from 97% identity to spe:Spro_2617)

Predicted SEED Role

"Transcriptional repressor protein TyrR" in subsystem Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) or Phenylalanine and Tyrosine Branches from Chorismate

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (523 amino acids)

>IAI46_13470 transcriptional regulator TyrR (Serratia liquefaciens MT49)
MRLEVFCEDRIGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFSQLDFDTFRALMAEIRR
IAGVTDVRTVNFMPSEREHRALRALLESMPEPVFSIDMKGKVELANPAAQALFGFSEDKI
RNQTATALIGGYNFSRWLESEQATPQSERVVIRSQDFLMDITPIYLEDENQQKDTVGAVV
MLKSTARMGRQLQNLSVNDDTEFDHIVAASPKMRQVLDQARKLAMLDAPLLIVGDTGTGK
DILARACHLRSPRGKQPFLALNCAALPDDVAESELFGHAPGAYPNALEGKKGFFEQAHGG
SVLLDEIGEMSPRMQTKLLRFINDGTFRRVGEEHEVHVDVRVICATQKNLTELVQRGEFR
EDLYYRLNVLTITLPPLRERPQDIMPLTELFVARFADEQGVARPKLSNDLGSFLSKYGWP
GNVRQLKNAIYRALTQTEGFELRPQDIVLPEFEVEMSLGDEVLDGSLDDISKRFERSVLT
RLYRTYPSTRKLAKRLGVSHTAIANKLREYGLSSRKPAGESEE