Protein Info for IAI46_11780 in Serratia liquefaciens MT49

Annotation: guanine deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02967: guanine deaminase
  • amino acids 31 to 430 (400 residues), 597.6 bits, E=5.7e-184
• PF01979: Amidohydro_1
  • amino acids 72 to 433 (362 residues), 228.1 bits, E=1.9e-71
• PF07969: Amidohydro_3
  • amino acids 260 to 434 (175 residues), 44.4 bits, E=1.7e-15

Best Hits

Swiss-Prot: 64% identical to GUAD_ECOLI: Guanine deaminase (guaD) from Escherichia coli (strain K12)

KEGG orthology group: K01487, guanine deaminase [EC: 3.5.4.3] (inferred from 92% identity to spe:Spro_2299)

MetaCyc: 64% identical to guanine deaminase (Escherichia coli K-12 substr. MG1655)
Guanine deaminase. [EC: 3.5.4.3]

Predicted SEED Role

"Guanine deaminase (EC 3.5.4.3)" in subsystem Purine Utilization or Purine conversions (EC 3.5.4.3)

MetaCyc Pathways

• purine nucleotides degradation II (aerobic) (11/11 steps found)
• purine nucleotides degradation I (plants) (10/12 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• guanosine nucleotides degradation III (4/4 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• superpathway of purines degradation in plants (13/18 steps found)
• purine nucleobases degradation II (anaerobic) (17/24 steps found)
• drosopterin and aurodrosopterin biosynthesis (4/7 steps found)
• purine nucleobases degradation I (anaerobic) (6/15 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.4.3

Protein Sequence (443 amino acids)

>IAI46_11780 guanine deaminase (Serratia liquefaciens MT49)
MNMPFTTAIRGNFFDIAACVDHPQQLGQQLRHIPDGLMLLHEGAIAWFGSWQQGESLLPP
GFEVAHYPDKLIVPGFIDTHIHYPQTEMIGAYGEQLLTWLKNYTFPIESQFCCERHSDKM
SAFFLQQLLSNGTTTALVFGTVHPQSVEALFRQAAALNMRLIAGKVMMDRHAPEALLESP
EQSYRQTRALIERWHGKQRLSYAITPRFAPTSTPALLEQVQRLRQEFPDAYLHTHLSENL
DEVAWVKELFPDSRSYLDVYHQYGLTGEKSVFAHCLHLEEQEWDCLCQTRSAIAFCPTSN
LFLGSGLFNLQKAWQKQVRLGIGTDVGAGTTFNMLETLGEAYKVAQLQRYQLSACEAFYH
ATLGGARALSLDDKIGNFDVGKEADFVVLDPAVSPLQKLRHENSRELAEQLFVLMTLGDD
RNVYRTYVDGKVVYRAAKCQEAA