Protein Info for IAI46_08290 in Serratia liquefaciens MT49
Annotation: L-serine ammonia-lyase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 78% identical to SDHM_ECOLI: L-serine dehydratase 2 (sdaB) from Escherichia coli (strain K12)
KEGG orthology group: K01752, L-serine dehydratase [EC: 4.3.1.17] (inferred from 97% identity to spe:Spro_1629)MetaCyc: 78% identical to L-serine deaminase II (Escherichia coli K-12 substr. MG1655)
L-serine ammonia-lyase. [EC: 4.3.1.17]
Predicted SEED Role
No annotation
MetaCyc Pathways
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (13/15 steps found)
- D-serine degradation (3/3 steps found)
- L-cysteine degradation II (3/3 steps found)
- L-serine degradation (3/3 steps found)
- glycine degradation (3/3 steps found)
- L-methionine biosynthesis II (5/6 steps found)
- L-tryptophan degradation II (via pyruvate) (2/3 steps found)
- purine nucleobases degradation II (anaerobic) (17/24 steps found)
- glycine betaine degradation I (5/8 steps found)
- glycine betaine degradation III (4/7 steps found)
- felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis (2/5 steps found)
- L-mimosine degradation (4/8 steps found)
- glutathione-mediated detoxification I (3/8 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.3.1.17
Use Curated BLAST to search for 4.3.1.17
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (455 amino acids)
>IAI46_08290 L-serine ammonia-lyase (Serratia liquefaciens MT49) MVSVFDIFKIGIGPSSSHTVGPMKAGKLFADELIASQQLMDTTRVVVDVYGSLSLTGKGH HTDIAIIMGLAGNLPHDVDIDGIAGFIRDVEQRGRLLMAKGHHEVDFPLQTSMNFHSNNL PLHENGMCISAFADERLLHSKTYYSTGGGFIVDEEHFGLSEANPVQVPFPFNSARDLQQH CKDAGLSLSGLVMQNELALHSKAEIDAHFAEVWQVMRAGIERGMNTEGLLPGPMKVQRRA AALRRILVTGDKNNIDPMNVVDWINMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYY DQFIRPVNPNSYSRYFLTSGVIGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELMGG SPAQVCIAAEIAMEHHLGLTCDPLAGQVQVPCIERNAISAVKAVNAARMALRRTSEPRVC LDKVIETMYETGKDMNAKYRETSQGGLAIKVVACN