Protein Info for IAI46_07910 in Serratia liquefaciens MT49

Annotation: HTH-type transcriptional regulator GalS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 345 PF00356: LacI" amino acids 8 to 53 (46 residues), 71.5 bits, see alignment 8e-24 PF00532: Peripla_BP_1" amino acids 65 to 280 (216 residues), 70.7 bits, see alignment E=3e-23 PF13407: Peripla_BP_4" amino acids 68 to 283 (216 residues), 54 bits, see alignment E=3.9e-18 PF13377: Peripla_BP_3" amino acids 175 to 334 (160 residues), 114.4 bits, see alignment E=1.2e-36

Best Hits

Swiss-Prot: 71% identical to GALS_ECOLI: HTH-type transcriptional regulator GalS (galS) from Escherichia coli (strain K12)

KEGG orthology group: K02529, LacI family transcriptional regulator (inferred from 96% identity to spe:Spro_1562)

Predicted SEED Role

"Mgl repressor and galactose ultrainduction factor GalS, HTH-type transcriptional regulator" in subsystem Lactose and Galactose Uptake and Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (345 amino acids)

>IAI46_07910 HTH-type transcriptional regulator GalS (Serratia liquefaciens MT49)
MTSVHPTTIRDVAKRAGVSVATVSRVLNHSALTSKETREQVLKAVAELGYRPNANAQALA
TQSSDTLGVVVMDVSDPFFGALVKAVDTVAQQHHKYLLIGNSYHQADKERHAIEVLIRQR
CNALIVHAKTLCDAELIAFLDQVPGMVLINRIIPGYEHRCVGLDNVSGAEMAMRLLLSQG
HQRIGYLGSNHPIEDGPLRQQGYTQAMAAAGLATPDSWRAYGSPDLQGGEEAMIELLGRN
LHLSAVFSYNDAMAAGAMAVLKENGITVPQNFSLVGFDDIPIARYTSPKLTTVRYPIVTM
ATLATELALLGAAGKLEPQARHLFMPTLVRRHSVAPWQSEAAVTL