Protein Info for IAI46_03205 in Serratia liquefaciens MT49

Annotation: glutathione-regulated potassium-efflux system protein KefC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 617 transmembrane" amino acids 12 to 45 (34 residues), see Phobius details amino acids 56 to 75 (20 residues), see Phobius details amino acids 87 to 110 (24 residues), see Phobius details amino acids 116 to 136 (21 residues), see Phobius details amino acids 148 to 171 (24 residues), see Phobius details amino acids 179 to 203 (25 residues), see Phobius details amino acids 216 to 235 (20 residues), see Phobius details amino acids 240 to 259 (20 residues), see Phobius details amino acids 271 to 290 (20 residues), see Phobius details amino acids 296 to 316 (21 residues), see Phobius details amino acids 328 to 350 (23 residues), see Phobius details amino acids 360 to 380 (21 residues), see Phobius details PF00999: Na_H_Exchanger" amino acids 12 to 375 (364 residues), 210.6 bits, see alignment E=3.4e-66 TIGR00932: transporter, monovalent cation:proton antiporter-2 (CPA2) family" amino acids 15 to 286 (272 residues), 294.6 bits, see alignment E=3.9e-92 PF02254: TrkA_N" amino acids 403 to 513 (111 residues), 96.3 bits, see alignment E=1.6e-31

Best Hits

Swiss-Prot: 73% identical to KEFC_SALSV: Glutathione-regulated potassium-efflux system protein KefC (kefC) from Salmonella schwarzengrund (strain CVM19633)

KEGG orthology group: None (inferred from 96% identity to srr:SerAS9_0650)

MetaCyc: 73% identical to K+ : H+ antiporter KefC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-42

Predicted SEED Role

"Glutathione-regulated potassium-efflux system protein KefC" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (617 amino acids)

>IAI46_03205 glutathione-regulated potassium-efflux system protein KefC (Serratia liquefaciens MT49)
MDNHQMMIEGLIYLGSAALFVPIAVRLGLGSVLGYLIAGCIIGPWGLKLVSDAESILTFA
EIGVVLMLFIIGLELDPKRLWTLRASVFGGGIIQMAACGLALSAFCYFLGLNWKVALLIG
LTLALSSTAIAMQAMSERNLTPSPIGRSAFAALLFQDIAAIPLVAMIPLLASSGATTTLA
AFSLSAAKVVGALAIVVLLGRYVTRPLLHFVARSGMREVFSAVALFLVFGFGILLEMAGL
SMAMGAFLAGVLLASSEYRHALESDIQPFKGLLLGLFFIGVGMSIDFGTLFHHPLLIASL
LLGFMLIKAALLWLIGPWLGVPKRQRGMFAILLGQGSEFAFVIFGAAQLAGVLPPDWAKS
LTLAVALSMAATPLLLVVATRLEKNTPKDERPADVIDEENASVIIAGFGRFGQIAGRLLL
ANGVHTVVLDHDPDHIETLRKFDTKVFYGDATRADLLEAAGAEHAKVLINAIDDVEANLQ
LTELAKRHFPHLKVVARARDVDHWYQLRQLGVEKPERETFESSLRIGRETLELLGLDAYE
AREKADTFRRYNLKMLEDTLDNYQDTEFRVASLQRAKEMLSAAIEQDQDRLARVPQSGWR
GSIDGKAPEDEVVEAKG