Protein Info for IAI46_02405 in Serratia liquefaciens MT49

Annotation: DEAD/DEAH box helicase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1137 PF13643: DUF4145" amino acids 24 to 111 (88 residues), 31.9 bits, see alignment 3.9e-11 PF04313: HSDR_N" amino acids 149 to 316 (168 residues), 32.3 bits, see alignment E=3.3e-11 PF04851: ResIII" amino acids 363 to 510 (148 residues), 117.2 bits, see alignment E=2.5e-37 PF18766: SWI2_SNF2" amino acids 365 to 573 (209 residues), 65.5 bits, see alignment E=2.1e-21 PF00270: DEAD" amino acids 366 to 511 (146 residues), 39.8 bits, see alignment E=1.4e-13 PF08463: EcoEI_R_C" amino acids 979 to 1119 (141 residues), 79.9 bits, see alignment E=8.2e-26

Best Hits

KEGG orthology group: K01153, type I restriction enzyme, R subunit [EC: 3.1.21.3] (inferred from 92% identity to sbo:SBO_4158)

Predicted SEED Role

"Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)" in subsystem Restriction-Modification System (EC 3.1.21.3)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.21.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1137 amino acids)

>IAI46_02405 DEAD/DEAH box helicase family protein (Serratia liquefaciens MT49)
MEQSLNFEMLRSQWPELAELGCMAERYIHSDPESCLVKLRNYTELMVRWLYRQERLPEGF
KANLYDLMNADVFASMMPEAIVMKMDALRIHGNRAAHGGRIKAKDTYWLLKEAYLLGVWL
YVRYANGNVDHSPKFSLPPLTLSPNRADEKHLKDAIKAQDESRERELALQRALQQEQEKA
EILTQRLNEARTRNQHVADILSIDEAETRRRLIDSRLLAAGWDVGDELKNTDHVTQEHPV
KEQPTSTGDGYADYVLWDEAHKPLAVVEAKKASVSAEQGRIQARLYADWLEKEYGQRPVI
FYTNGYDIWLWDDNKTHGYPPRRIFGFYGKESLQYLIQQRETRLPLNSIPHVKDNEGKAV
AGRLYQLETIARVSERFTNKYRQSLIVQATGTGKTRVAIALSKLMIDARWVKRILFLCDR
RELRKQAANAFNQFTNEPLYVVGKSKKEDRQNARIYIATYPGMMKIMDHFDVGYFDLIIA
DESHRSIYNVYGDVFKYFDALQIGLTATPIDMVSKTTFGLFGCEGRIPTANYSLEDAIAD
NNLVPYEVVTHTTEFLREGIKREKLSDQQIRELEDQGVDPNTLEFEGKSLDEAIYNNDTN
RHILRNLMENGLKDADGQLPGKTIIFARNHKHALLLNKLFDEMYPQFAGHFCQVIDNYDP
RAEQLIDDFKGLDESTNKELTLAISVDMLDTGIDVPEIVNLVFAKPVKSKVKFWQMIGRG
TRLCPGLYGNDENGNSLDKQKFRIFDHWGNFEYHELHTEEAEVKPTKSLAQKRFEAWVLL
GAAAQRKFDKHAVDLVARQLREQINALDEKSIAVQEKWQQKAQYTDEKLLRQLSPKTQQD
LLSILAPLMQWLDVRGQSDAMRFDMDILAAQTARYANPEELDVLWPEIVKKIERLPPHLS
QVQQQGQRINQLHDLSWWKQASLEELEDIRIHLRGIMHLMEKDPTPQFRSLLVDITEDAG
QIQTETRKTNVRSIDFKLYRQQVQGALEPLFQQNPVLKKIRNGETVTQSELDELTKLVLI
QNPNVDIRALKEFYPQATASLDKLLRTIIGMDSDAVEVRFAQFAADNNLTSPQLRFLSLL
KNHIRDYGTIEMKQLFEQPFTQIHGEGVTGIFPDMQQIVTLQKIVEELGVVIPSPAL