Protein Info for HUW76_04550 in Fusobacterium nucleatum SB010
Annotation: imidazolonepropionase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 98% identical to HUTI_FUSNN: Imidazolonepropionase (hutI) from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)
KEGG orthology group: K01468, imidazolonepropionase [EC: 3.5.2.7] (inferred from 98% identity to fnu:FN0740)MetaCyc: 53% identical to imidazolone-5-propionate hydrolase (Bacillus subtilis)
Imidazolonepropionase. [EC: 3.5.2.7]
Predicted SEED Role
"Imidazolonepropionase (EC 3.5.2.7)" in subsystem Histidine Degradation (EC 3.5.2.7)
MetaCyc Pathways
- L-histidine degradation III (6/6 steps found)
- L-histidine degradation VI (7/8 steps found)
- L-histidine degradation I (4/4 steps found)
- L-histidine degradation II (3/5 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 3.5.2.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (413 amino acids)
>HUW76_04550 imidazolonepropionase (Fusobacterium nucleatum SB010) MQADLVLYNIGQLVTSRELDKTKKMDNIEVIENNGYIIIEKDKIVAVGSGEVPKEYLTPA TEMVDLSGKLVTPGLIDSHTHLVHGGSRENEFAMKIAGVPYLEILEKGGGILSTLKSTRN ASEKELIEKTLKSLKHMLELGVTTVEAKSGYGLNLKDELKQLEVTKILGYLQPVTLVSTF MAAHATPPEYKNNKEGYVQEVIKMLPIVKERNLAEFCDIFCEDKVFSVDESRRILTAAKE LGYKLKIHADEIVSLGGVELAAEIGATSAEHLMKITDSGINALANSNVIADLLPATSFNL MEHYAPARKMIEAGIQIALSTDYNPGSCPSENLQFVMQIGAAHLKMTPKEVFKAVTINAA KAIDKQDIIGSIEVGKKADITVFDAPSMAYFLYHFGINHTDSVYKNGKLVFKK