Protein Info for HUW76_02835 in Fusobacterium nucleatum SB010

Annotation: RNA methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 187 PF09936: Methyltrn_RNA_4" amino acids 4 to 185 (182 residues), 271.7 bits, see alignment E=1.6e-85

Best Hits

Swiss-Prot: 47% identical to Y1570_THEMA: Uncharacterized protein TM_1570 (TM_1570) from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

KEGG orthology group: None (inferred from 96% identity to fnu:FN0282)

Predicted SEED Role

"tRNA (Guanine37-N1) -methyltransferase (EC 2.1.1.31)" in subsystem Ribosome biogenesis bacterial or Wyeosine-MimG Biosynthesis (EC 2.1.1.31)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.31

Use Curated BLAST to search for 2.1.1.31

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (187 amino acids)

>HUW76_02835 RNA methyltransferase (Fusobacterium nucleatum SB010)
MRNKVYLSLVHYPVYNRNKDIVCTSVTNFDIHDISRSCGTYEIKGYRLVVPVDAQKKLTE
RIIAYWQDGTGGQYNKDREQAFKVTDVAESIENVVKEIEKIEGQKPLIITTSARTFNNSI
SYKDLSKQIFEDDKPYLLLFGTGWGLTDEVMSMSDYILEPIRANSKYNHLSVRAAVAIIL
DRLFGEK