Protein Info for HUW76_01940 in Fusobacterium nucleatum SB010

Annotation: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 332 TIGR00557: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA" amino acids 4 to 324 (321 residues), 318.8 bits, see alignment E=2.3e-99 PF04166: PdxA" amino acids 32 to 321 (290 residues), 342.4 bits, see alignment E=1.1e-106

Best Hits

Swiss-Prot: 92% identical to PDXA2_FUSNN: Putative D-threonate 4-phosphate dehydrogenase (FN0226) from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)

KEGG orthology group: K00097, 4-hydroxythreonine-4-phosphate dehydrogenase [EC: 1.1.1.262] (inferred from 92% identity to fnu:FN0226)

MetaCyc: 61% identical to 4-phospho-D-erythronate 3-dehydrogenase (Heliomicrobium modesticaldum Ice1)
RXN-18601 [EC: 1.1.1.409]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.262 or 1.1.1.409

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (332 amino acids)

>HUW76_01940 4-hydroxythreonine-4-phosphate dehydrogenase PdxA (Fusobacterium nucleatum SB010)
MRTKIAIPMGDPAGVGAEIIVKTAVSNEILNLCDLVVIGDKNVLEKAIEICKVDLKIHII
KNVEDGKYEKGILNVIDLQNIDMDSLEYGKIQGMCGKAAFEYIKKSVELAMAHKVDAIAT
TPINKESLKAGNVNYIGHTEILGDLSNSKDPLTMFEVDNMRVFFLTRHMSLRNACDAVTK
ERVLEYIKRCTKALKQLGVSGKMAVAGLNPHSGEHGLFGNEEVKEITPAIEEAQKLGYDV
VGPIGADSVFHQALQGRYVAVLSLYHDQGHIATKTYDFERTIAITLDMPILRTSVDHGTA
FDIAGKGIVSAVSMIEAVKLAAKYAPNFKNIK