Protein Info for HUW76_01035 in Fusobacterium nucleatum SB010

Annotation: translation initiation factor IF-2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 747 PF04760: IF2_N" amino acids 12 to 60 (49 residues), 46.8 bits, see alignment 6.1e-16 amino acids 171 to 217 (47 residues), 36.7 bits, see alignment 8.7e-13 TIGR00487: translation initiation factor IF-2" amino acids 165 to 746 (582 residues), 787.7 bits, see alignment E=8.3e-241 TIGR00231: small GTP-binding protein domain" amino acids 249 to 406 (158 residues), 117.9 bits, see alignment E=3.8e-38 PF00009: GTP_EFTU" amino acids 251 to 407 (157 residues), 126.7 bits, see alignment E=2.5e-40 PF01926: MMR_HSR1" amino acids 252 to 357 (106 residues), 40.6 bits, see alignment E=7.3e-14 PF00071: Ras" amino acids 253 to 407 (155 residues), 29.1 bits, see alignment E=2.2e-10 PF11987: IF-2" amino acids 523 to 636 (114 residues), 122.9 bits, see alignment E=2e-39 PF03144: GTP_EFTU_D2" amino acids 667 to 734 (68 residues), 37.5 bits, see alignment E=8.1e-13

Best Hits

Swiss-Prot: 96% identical to IF2_FUSNN: Translation initiation factor IF-2 (infB) from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131)

KEGG orthology group: K02519, translation initiation factor IF-2 (inferred from 96% identity to fnu:FN2020)

Predicted SEED Role

"Translation initiation factor 2" in subsystem NusA-TFII Cluster or Translation initiation factors eukaryotic and archaeal or Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (747 amino acids)

>HUW76_01035 translation initiation factor IF-2 (Fusobacterium nucleatum SB010)
MNKRLKEGEYMKVRVHELAKKHDIKNKEFLEILKKDIGINVTSHLSNLDEDQVKKIDDYF
AKMNMLKVEMPEPTKAHKEKKEEKPIRKIMVEDENDENEGYSQKNNKKAKFQQTKNKKNN
NITFDEDGNSHKNRSKKKKGRRTDFVLKTIEATPDVVEEDGIKIIKFRGELTLGDFAEKL
GVNSAELIKKLFLKGQMLTINSPISLSMAEDLAADYDVLVEEEQEVELDFGEKFDLEIED
KAADLKERPPVITIMGHVDHGKTSLLDAIRTTNVVEGEAGGITQKIGAYQVVKDGKRITF
IDTPGHEAFTDMRARGAQVTDIAILVVAADDGVMPQTVEAISHAKVAKVPIIVAVNKIDK
PEANPMKVKQELMEHGIVSSEWGGDVEFVEVSAKKKINLDGLLDTILITAEILELKGNTK
KRAKGVVLESRLDPKIGPIADILVQEGTLKIGDVIVAGEVQGKVKALLNDKGERVNNATV
SQPVEVIGFNNVPDAGDTMYVIQNEQHAKRIVEEVRKERKIQETTKKTISLESLSDQFKH
EDLKELNLILRADSKGSVDALRDSLLKLSNDEVAVSIIQAASGAITESDVKLAEAAGAII
IGYNVRPTTKALKEAEISKVEIRTSGIIYHITEDIEKALAGMLEPEYKEEYLGRIEIKKV
FKVSKVGNVAGCVVIDGKVKNDSNIRILRDNVVIYEGKLASLKRFKDDAKEVVAGQECGL
GVENFNDIKEGDVVEAFEMVEVKRTLK