Protein Info for HMPREF1181_RS12585 in Bacteroides stercoris CC31F

Annotation: MIP family channel protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 225 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 34 to 56 (23 residues), see Phobius details amino acids 84 to 104 (21 residues), see Phobius details amino acids 124 to 143 (20 residues), see Phobius details amino acids 155 to 175 (21 residues), see Phobius details amino acids 197 to 220 (24 residues), see Phobius details PF00230: MIP" amino acids 2 to 215 (214 residues), 199 bits, see alignment E=4.6e-63 TIGR00861: MIP family channel proteins" amino acids 6 to 217 (212 residues), 186.2 bits, see alignment E=3.7e-59

Best Hits

Swiss-Prot: 46% identical to AQPZ_VIBVU: Aquaporin Z (aqpZ) from Vibrio vulnificus (strain CMCP6)

KEGG orthology group: K06188, aquaporin Z (inferred from 89% identity to bhl:Bache_0608)

MetaCyc: 43% identical to water channel AqpZ (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-145

Predicted SEED Role

"Aquaporin Z"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (225 amino acids)

>HMPREF1181_RS12585 MIP family channel protein (Bacteroides stercoris CC31F)
MKKYIAEMLGTMVLVLMGCGTAVSLSCTSADPNLAATVIGTALAFGLSVVAMAYTIGGVS
GCHINPAITLGCLLSGRMSGKDAGMYMLFQVIGAILGSAVLWVLTSNAGVSGTGANACQE
GVSVTGALLAEIVFTFVFVLVVLGTTDAKKGAGNFAGLAIGLSLVLVHLACIRYTGTSVN
PARSIGPALFQGGEALSQLWIFIVGPFIGAVLSAGVWKIFAGGKE