Protein Info for HMPREF1181_RS08045 in Bacteroides stercoris CC31F

Annotation: HD domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 474 PF01743: PolyA_pol" amino acids 32 to 160 (129 residues), 95.9 bits, see alignment E=3.6e-31 PF12627: PolyA_pol_RNAbd" amino acids 187 to 246 (60 residues), 63.2 bits, see alignment E=2.4e-21 PF01966: HD" amino acids 264 to 381 (118 residues), 47.1 bits, see alignment E=4.2e-16

Best Hits

KEGG orthology group: K00970, poly(A) polymerase [EC: 2.7.7.19] (inferred from 90% identity to bfr:BF3640)

Predicted SEED Role

"tRNA nucleotidyltransferase (EC 2.7.7.21) (EC 2.7.7.25)" in subsystem Polyadenylation bacterial or tRNA nucleotidyltransferase (EC 2.7.7.21, EC 2.7.7.25)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.19 or 2.7.7.21 or 2.7.7.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (474 amino acids)

>HMPREF1181_RS08045 HD domain-containing protein (Bacteroides stercoris CC31F)
MIELTTEELKQRFSDSIFKRISETADELGLECYVVGGYVRDIFLQRPSKDIDVVVVGSGI
AMAEALARRLGRGAHLSVFKNFGTAQLKYHGTEVEFVGARKESYTHDSRKPIVEDGSLED
DQNRRDFTINALAVCLNSQRYGELVDPFGGMADMKEKTIRTPLDPDITFSDDPLRMMRCI
RFATQLNFYIDDDTFESLYRNKERISIISKERIADELNKILLSPVPSKGFIDLDRSGLLQ
LIFPELVALQGVETRNGRAHKDNFYHTLEVLDNISKKTDNLWLRWAALLHDIAKPATKRW
EPRAGWTFHNHNFIGEKMIPDIFRRMKLPMNEKMKYVQKLVGLHMRPIVIADDVVTDSAV
RRLLFEAGDDIDDLMTLCEADITSKNMERKQRFLNNFQLVRQKLKDLEERDRIRNFQPPV
SGEEIMKTFNLPPCQQVGALKSAIKDAILDGVIPNEYEAARAFMLQRAEKMGLK