Protein Info for HMPREF1181_RS07780 in Bacteroides stercoris CC31F

Annotation: peptide-methionine (R)-S-oxide reductase MsrB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 351 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details TIGR00401: peptide-methionine (S)-S-oxide reductase" amino acids 35 to 185 (151 residues), 202.6 bits, see alignment E=4.2e-64 PF01625: PMSR" amino acids 36 to 186 (151 residues), 210.4 bits, see alignment E=1.6e-66 TIGR00357: methionine-R-sulfoxide reductase" amino acids 210 to 343 (134 residues), 206.8 bits, see alignment E=1.1e-65 PF01641: SelR" amino acids 215 to 334 (120 residues), 173.4 bits, see alignment E=1.7e-55

Best Hits

Swiss-Prot: 55% identical to MSRAB_STRP6: Peptide methionine sulfoxide reductase MsrA/MsrB (msrAB) from Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)

KEGG orthology group: K12267, peptide methionine sulfoxide reductase msrA/msrB [EC: 1.8.4.11 1.8.4.12] (inferred from 75% identity to bfs:BF3378)

Predicted SEED Role

"Peptide methionine sulfoxide reductase MsrA (EC 1.8.4.11) / Peptide methionine sulfoxide reductase MsrB (EC 1.8.4.12)" (EC 1.8.4.11, EC 1.8.4.12)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.4.11 or 1.8.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (351 amino acids)

>HMPREF1181_RS07780 peptide-methionine (R)-S-oxide reductase MsrB (Bacteroides stercoris CC31F)
MKQIIFIFVMLISCLSCVGKSTGQAERRNDMKSMKEIYLAGGCFWGTEHFLKQIEGVEVT
QVGYANGNIANPTYQQVCTGTTDFAETVKVQYDSDKVTLPFLIDLYFKTIDPTSLNRQGN
DRGTQYRTGIYYTDTADLPVIRETVSRLAANYTRPLEVEIEPLKNFYPAEEYHQDYLDKN
PGGYCHINPALFDLARKAKMKKPVAAYSKPDDATLRSQLTAEQYAVTQKNATEPPFRNAY
WDEHRPGIYVDITTGEPLFVSTDKFDSGCGWPSFSKPIDRKLIQEKADTTHGMVRTEVRS
KTGDAHLGHVFTDGPADKGGLRYCINSASLRFIPKEKMQAEGYGEYLELVK