Protein Info for HMPREF1181_RS03375 in Bacteroides stercoris CC31F

Annotation: isoprenyl transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 244 TIGR00055: di-trans,poly-cis-decaprenylcistransferase" amino acids 12 to 237 (226 residues), 287.8 bits, see alignment E=2.7e-90 PF01255: Prenyltransf" amino acids 19 to 237 (219 residues), 290.9 bits, see alignment E=3.2e-91

Best Hits

Swiss-Prot: 74% identical to ISPT_BACTN: Isoprenyl transferase (uppS) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K00806, undecaprenyl diphosphate synthase [EC: 2.5.1.31] (inferred from 80% identity to bhl:Bache_0322)

MetaCyc: 49% identical to ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] (Escherichia coli K-12 substr. MG1655)
Di-trans,poly-cis-decaprenylcistransferase. [EC: 2.5.1.31]

Predicted SEED Role

"Undecaprenyl diphosphate synthase (EC 2.5.1.31)" (EC 2.5.1.31)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.31

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (244 amino acids)

>HMPREF1181_RS03375 isoprenyl transferase (Bacteroides stercoris CC31F)
MLNKEELDLSRIPQHVAIIMDGNGRWAKLRGQERSYGHQAGAETVHVIAEEASKLGIKYL
TLYTFSTENWNRPSNEVAALMALLFDSIEEETFMKNNISFRVIGDLTKLPDNVRERLETC
IAHTANNTGMSLVLAISYSSRWEITEAARRLAVLVQKGELTPEQIDSTLLSQYLATDFMP
DPDLLIRTGGEIRLSNYLLWQCAYSELYFCDTYWPDFREAELHKAIHDYQKRERRFGKTS
EQIR