Protein Info for HMPREF1181_RS00165 in Bacteroides stercoris CC31F

Annotation: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02142: MGS
  • amino acids 21 to 132 (112 residues), 65.6 bits, E=3.7e-22
• PF01808: AICARFT_IMPCHas
  • amino acids 138 to 438 (301 residues), 363.7 bits, E=1e-112

Best Hits

Swiss-Prot: 91% identical to PUR9_BACTN: Bifunctional purine biosynthesis protein PurH (purH) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K00602, phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC: 2.1.2.3 3.5.4.10] (inferred from 95% identity to bhl:Bache_1145)

Predicted SEED Role

"IMP cyclohydrolase (EC 3.5.4.10) / Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3)" in subsystem De Novo Purine Biosynthesis (EC 2.1.2.3, EC 3.5.4.10)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (38/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (18/21 steps found)
• inosine-5'-phosphate biosynthesis II (5/5 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (20/26 steps found)
• inosine-5'-phosphate biosynthesis I (5/6 steps found)
• inosine-5'-phosphate biosynthesis III (4/6 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• One carbon pool by folate
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.2.3 or 3.5.4.10

Protein Sequence (507 amino acids)

>HMPREF1181_RS00165 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (Bacteroides stercoris CC31F)
MSETKRIKTALVSVYHKEGLDEIITKLHEEGVEFLSTGGTRQFIESLGYPCKAVEDLTTY
PSILGGRVKTLHPKIFGGILCRRGLEQDMQQIEKYEIPEIDLVIVDLYPFEATVASGAEE
PAIIEKIDIGGISLIRAAAKNYNDVVIVASQAQYQPLRDMLMEHGATTSLEERRWFAKEA
FAVSSHYDSAIFNYFDGEEGSAFRQSANNQKTLRYGENPHQKGYFYGNIDAMFDQIHGKE
ISYNNLLDINAAVDLIDEFTDTTFAILKHNNACGLASRPTVLEAWTDALAGDPVSAFGGV
LITNAVIDKAAAEEINKIFFEVIIAPDYDVDALEILGQKKNRIILVRKQAALPKKQFRSL
LNGVLVQDRDLKVETPEDLKTVTTKAPTAEEVEDMLFANKIVKNSKSNAIVLAKGKQLLA
SGVGQTSRVDALKQAIEKAKNFGFDLNGAVMASDAFFPFPDCVEIAGNEGVTAVIQPGGS
IKDELSFNYCNEHGIAMVITGFRHFKH