Protein Info for HGI48_RS19990 in Dickeya dianthicola 67-19

Annotation: homoserine/homoserine lactone efflux protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 206 transmembrane" amino acids 6 to 27 (22 residues), see Phobius details amino acids 39 to 64 (26 residues), see Phobius details amino acids 69 to 88 (20 residues), see Phobius details amino acids 116 to 138 (23 residues), see Phobius details amino acids 144 to 166 (23 residues), see Phobius details amino acids 186 to 203 (18 residues), see Phobius details PF01810: LysE" amino acids 14 to 202 (189 residues), 170.4 bits, see alignment E=1.6e-54

Best Hits

Swiss-Prot: 77% identical to RHTB_ECOL6: Homoserine/homoserine lactone efflux protein (rhtB) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K05834, homoserine/homoserine lactone efflux protein (inferred from 96% identity to ddc:Dd586_3860)

MetaCyc: 77% identical to L-homoserine/L-homoserine lactone/L-threonine exporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-242; TRANS-RXN-242A; TRANS-RXN0-0244

Predicted SEED Role

"Homoserine/homoserine lactone efflux protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9RIS8 at UniProt or InterPro

Protein Sequence (206 amino acids)

>HGI48_RS19990 homoserine/homoserine lactone efflux protein (Dickeya dianthicola 67-19)
MTQDWWLTYLVTTLILSLSPGSGAINTMSTSISHGYRGAIASIAGLQLGLTIHIVLVGIG
LGALLSQSVLAFDMLKWLGAAYLIWLGIQQWRSAGSLDLQTLANGMPRRRLFKRAILVNL
TNPKSIVFLAALFPQFIIPHQPQAMQYLVLGVTTVVVDIIVMIGYATLAQRIARWLKGPR
QLKQLNRTFGSLFMLVGALLATARKA