Protein Info for HGI48_RS11990 in Dickeya dianthicola 67-19
Annotation: L-threonine dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 68% identical to ADH2_ZYMMA: Alcohol dehydrogenase 2 (adhB) from Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1)
KEGG orthology group: K13954, alcohol dehydrogenase [EC: 1.1.1.1] (inferred from 97% identity to ddd:Dda3937_03796)MetaCyc: 68% identical to alcohol dehydrogenase II monomer (Zymomonas mobilis)
Alcohol dehydrogenase. [EC: 1.1.1.1]
Predicted SEED Role
"Alcohol dehydrogenase (EC 1.1.1.1)" in subsystem Fermentations: Mixed acid or Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 1.1.1.1)
MetaCyc Pathways
- hexitol fermentation to lactate, formate, ethanol and acetate (18/19 steps found)
- mixed acid fermentation (15/16 steps found)
- superpathway of anaerobic sucrose degradation (17/19 steps found)
- superpathway of N-acetylneuraminate degradation (18/22 steps found)
- heterolactic fermentation (15/18 steps found)
- 3-methylbutanol biosynthesis (engineered) (6/7 steps found)
- ethanol degradation II (3/3 steps found)
- pyruvate fermentation to ethanol I (3/3 steps found)
- pyruvate fermentation to ethanol III (3/3 steps found)
- ethanol degradation I (2/2 steps found)
- superpathway of fermentation (Chlamydomonas reinhardtii) (7/9 steps found)
- acetylene degradation (anaerobic) (4/5 steps found)
- ethanolamine utilization (4/5 steps found)
- pyruvate fermentation to isobutanol (engineered) (4/5 steps found)
- acetaldehyde biosynthesis I (1/1 steps found)
- phytol degradation (3/4 steps found)
- L-isoleucine degradation II (2/3 steps found)
- L-leucine degradation III (2/3 steps found)
- L-valine degradation II (2/3 steps found)
- pyruvate fermentation to ethanol II (1/2 steps found)
- (S)-propane-1,2-diol degradation (3/5 steps found)
- L-phenylalanine degradation III (2/4 steps found)
- L-tyrosine degradation III (2/4 steps found)
- L-methionine degradation III (1/3 steps found)
- cytidine-5'-diphosphate-glycerol biosynthesis (1/4 steps found)
- salidroside biosynthesis (1/4 steps found)
- serotonin degradation (3/7 steps found)
- superpathway of Clostridium acetobutylicum solventogenic fermentation (7/13 steps found)
- phenylethanol biosynthesis (1/5 steps found)
- butanol and isobutanol biosynthesis (engineered) (3/8 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (9/17 steps found)
- noradrenaline and adrenaline degradation (4/13 steps found)
- L-tryptophan degradation V (side chain pathway) (1/13 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- 3-Chloroacrylic acid degradation
- Drug metabolism - cytochrome P450
- Fatty acid metabolism
- Glycine, serine and threonine metabolism
- Glycolysis / Gluconeogenesis
- Metabolism of xenobiotics by cytochrome P450
- Retinol metabolism
- Tyrosine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.1
Use Curated BLAST to search for 1.1.1.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A7L9RE41 at UniProt or InterPro
Protein Sequence (382 amino acids)
>HGI48_RS11990 L-threonine dehydrogenase (Dickeya dianthicola 67-19) MSSAFYIPALNLMGEGALEEAARQIQLQGFKHALIVTDGVLNKIGVAASVQQLLKKYYID SAIYDGVQPNPTVANVDAGLKILKANHSDCVVSLGGGSSHDCAKGIALLATNGGEIADYE GVDVSAKPQLPLIGINTTAGTASEMTRFCIITDEVRHVKMAIVDKNVTPVMSVNDPVLMV GMPASLTAATGMDALTHAIEAYVSTAANPITDAVAIKAIELIRDHLRDAVKDGKNMVARE QMAYAQFMAGMAFNNASLGYVHAMAHQLGGFYNLPHGVCNAVLLPHVERYNASVASARLK DVAIALGVDVAGLSDRQGADAAIAAISQMAHDVGIPAGLKDLGVKEEDFNILADNALKDA CGVTNPKQATHAEIVEIFAAAF