Protein Info for HGI48_RS11855 in Dickeya dianthicola 67-19

Annotation: NAD-dependent succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 65% identical to GABD_ECOLI: Succinate-semialdehyde dehydrogenase [NADP(+)] GabD (gabD) from Escherichia coli (strain K12)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 96% identity to dze:Dd1591_1868)

MetaCyc: 69% identical to NAD(P)+-dependent succinate semialdehyde dehydrogenase monomer (Cupriavidus necator H16)
Succinate-semialdehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.16]; RXN-10823 [EC: 1.2.1.16]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

4-aminobutanoate degradation III (2/2 steps found)
L-lactaldehyde degradation (aerobic) (1/2 steps found)
homotaurine degradation (1/2 steps found)
superpathway of fucose and rhamnose degradation (8/12 steps found)
methylglyoxal degradation IV (1/3 steps found)
methylglyoxal degradation V (1/3 steps found)
lactate biosynthesis (archaea) (2/5 steps found)
superpathway of methylglyoxal degradation (4/8 steps found)
L-rhamnose degradation II (2/8 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9RE58 at UniProt or InterPro

Protein Sequence (486 amino acids)

>HGI48_RS11855 NAD-dependent succinate-semialdehyde dehydrogenase (Dickeya dianthicola 67-19)
MQLKNKTLFRQHSLIGGEWQDSFNGARLSVTNPATGAELGSIPLVTAEQTQQAISAAEQA
LSAWRQRTGKERAALMQAWAHLIRANQDDLAAILTAEQGKSLAEASGEIAYATSFIDWFA
EEAKRVEGSVLQSPQANQRLLVIKQGIGVCAAITPWNFPAAMITRKAAPALAAGCTMIVK
PAEQTPFTALALAELAQQAGIPAGVLQVVTGDAPAVGKVLCDSPVVRKLSFTGSTEVGRI
LMAQCAPTVKKLSLELGGNAPFIVFDDADLEQAIKGILASKFRNSGQTCVCANRIYVQRG
IYPALAARLVDEVEKLKVGDGTQPGVMQGPLIDQDAVGKVEQHIDDALSKGAELLTGGSR
HALGGTFFTPTVIGGVTRDMRFAREETFGPVAPLFPFDDEAQAVAMANDTEFGLAAYVYT
RDAVRQWRVPEALEYGMVGINTGLISNEVAPFGGVKQSGLGREGSRFGIEEYLEMKYLCV
DLTPSA