Protein Info for HGI48_RS08685 in Dickeya dianthicola 67-19

Annotation: malonyl-ACP O-methyltransferase BioC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 260 TIGR02072: malonyl-acyl carrier protein O-methyltransferase BioC" amino acids 21 to 259 (239 residues), 213.6 bits, see alignment E=2e-67 PF01209: Ubie_methyltran" amino acids 40 to 164 (125 residues), 51.1 bits, see alignment E=3.7e-17 PF13489: Methyltransf_23" amino acids 41 to 184 (144 residues), 39.6 bits, see alignment E=1.3e-13 PF13847: Methyltransf_31" amino acids 50 to 165 (116 residues), 63.3 bits, see alignment E=6.7e-21 PF08242: Methyltransf_12" amino acids 56 to 144 (89 residues), 50.1 bits, see alignment E=1.1e-16 PF08241: Methyltransf_11" amino acids 56 to 147 (92 residues), 92.3 bits, see alignment E=7.5e-30 PF13649: Methyltransf_25" amino acids 56 to 143 (88 residues), 77.9 bits, see alignment E=2.4e-25

Best Hits

Swiss-Prot: 59% identical to BIOC_PECAS: Malonyl-[acyl-carrier protein] O-methyltransferase (bioC) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K02169, biotin synthesis protein BioC (inferred from 91% identity to ddd:Dda3937_03750)

MetaCyc: 47% identical to malonyl-acyl carrier protein methyltransferase (Escherichia coli K-12 substr. MG1655)
RXN-11475 [EC: 2.1.1.197]

Predicted SEED Role

"SAM-dependent methyltransferase, BioC-like"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.197

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9RCH7 at UniProt or InterPro

Protein Sequence (260 amino acids)

>HGI48_RS08685 malonyl-ACP O-methyltransferase BioC (Dickeya dianthicola 67-19)
MTPVNASSLSYSPHKQAIAHAFGRAAGDYDRFAALQRESGEQLMALVGDHAGSELLDAGC
GTGYFSARWQASGKQVTALDLSTEMLAIARQRRAATHYLQGDIEHLPLADGSVDISFSNM
AMQWCDDFDAGLAELYRVTRPGGAIAICTLAQGTLAELDAAWRQLDGSRRINRFLSLEAV
VSACRRYHADVSLAPVTCYFPDVLSLMRSVKGVGATWLRDGREHGGLSRRHLTALTAHYD
RHPQGYPLTYQRVFGVIYRD