Protein Info for HGI48_RS06740 in Dickeya dianthicola 67-19

Annotation: tyrosine-protein kinase Wzc

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 726 transmembrane" amino acids 32 to 51 (20 residues), see Phobius details amino acids 425 to 447 (23 residues), see Phobius details PF02706: Wzz" amino acids 16 to 107 (92 residues), 76.5 bits, see alignment E=5.7e-25 PF13807: GNVR" amino acids 367 to 447 (81 residues), 114.4 bits, see alignment E=6.4e-37 TIGR01007: capsular exopolysaccharide family" amino acids 509 to 710 (202 residues), 159.2 bits, see alignment E=4.8e-51 PF10609: ParA" amino acids 528 to 697 (170 residues), 33.8 bits, see alignment E=8.7e-12 PF01656: CbiA" amino acids 531 to 661 (131 residues), 28.1 bits, see alignment E=6e-10 PF13614: AAA_31" amino acids 532 to 653 (122 residues), 40.8 bits, see alignment E=8.2e-14 PF00142: Fer4_NifH" amino acids 538 to 594 (57 residues), 26.6 bits, see alignment 1.5e-09

Best Hits

Swiss-Prot: 53% identical to ETK_ECO57: Tyrosine-protein kinase etk (etk) from Escherichia coli O157:H7

KEGG orthology group: None (inferred from 92% identity to ddd:Dda3937_03927)

MetaCyc: 53% identical to protein-tyrosine kinase Etk (Escherichia coli K-12 substr. MG1655)
Receptor protein-tyrosine kinase. [EC: 2.7.10.1, 2.7.10.2, 2.7.10.3, 2.7.12.1]

Predicted SEED Role

"Tyrosine-protein kinase Wzc (EC 2.7.10.2)" in subsystem Colanic acid biosynthesis (EC 2.7.10.2)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.10.1 or 2.7.10.2 or 2.7.10.3 or 2.7.12.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A7L9RBJ6 at UniProt or InterPro

Protein Sequence (726 amino acids)

>HGI48_RS06740 tyrosine-protein kinase Wzc (Dickeya dianthicola 67-19)
MSEKIAVKTSEANKADEIDLGRLLGTVLDHCWLIISIITIFTMLGILYTLLATPIYQSDA
LVQVEQNSSDNLLKDISSVLPDAKPDSSAEIELIQSRMVIGKTVQDLSLDTEVKEKFFPV
VGKGLARLLGRTPGQILVSRLSVPALQRDEPMKLEVLGNGAYRLERKDEGTFEGKVGQLA
SHDGVELLVSDIDAVPGTVFVVTKKNELSAINDVLNNLTVADKGKDTGILDLTLSGEDPV
LINKILNSISHNYLEQNVERKSEEAGKSLVFLQQQLPVVRTSLEDSENKLNKFRQQNDSV
DLSLEAKSVLDTIVDVESQLNQLTFREAEISKLYTREHPAYRALLEKRVTLEKERNSLNK
RVSSMPKTQQEILRLTRDVNVGQEVYVQLMNKQQELSISKASTVGNVRIIDPAEVQIKPV
KPKKALVILLSVVLGGVIAVSFVLLKTLLHHGIESPEQLEELGINVYASVPLSEWQQKKD
REFVGKNRKQNARSHSLLAVGNPADLAIEAIRSLRTSLHFAMMEAKNNVLMISGASPGIG
KSFISANLGAVIAQAGQRVLIVDCDMRKGYAHHMLGTTADKGLSDILSGQVEAEKATRST
AVTNMFFIPRGQIPPNPSELLMHKNFVAFVEWAAQSFDIVLLDTPPILAVTDAAIISRQA
GTSLLVARFETNTPKEVEISIRRFEQNGAPIKGVILNAVIRRALSYYSYGYDSYQYSYDS
DKKNSV