Protein Info for HER17_RS18710 in Pectobacterium carotovorum WPP14

Annotation: tagaturonate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01232: Mannitol_dh
  • amino acids 17 to 172 (156 residues), 105.4 bits, E=3.5e-34
• PF08125: Mannitol_dh_C
  • amino acids 203 to 463 (261 residues), 213.6 bits, E=3.2e-67

Best Hits

Swiss-Prot: 98% identical to UXAB_PECCP: Altronate oxidoreductase (uxaB) from Pectobacterium carotovorum subsp. carotovorum (strain PC1)

KEGG orthology group: K00041, tagaturonate reductase [EC: 1.1.1.58] (inferred from 97% identity to pwa:Pecwa_0747)

MetaCyc: 73% identical to tagaturonate reductase (Escherichia coli K-12 substr. MG1655)
Tagaturonate reductase. [EC: 1.1.1.58]

Predicted SEED Role

"Altronate oxidoreductase (EC 1.1.1.58)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 1.1.1.58)

MetaCyc Pathways

• superpathway of hexuronide and hexuronate degradation (9/10 steps found)
• D-galacturonate degradation I (5/5 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (19/31 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.58

Protein Sequence (488 amino acids)

>HER17_RS18710 tagaturonate reductase (Pectobacterium carotovorum WPP14)
MQTLNRRNFPGRQHPDRVIQFGEGNFLRAFVDWQLDLLNEHTDLDAGIVVVRPIDSDFPP
ALDTQDGLYTTIIRGLNEQGEAVREPRLIRSVNREINVYRQFDEYLALAHDPNIRFVFSN
TTEAGISYHADDRLNDAPPVSFPAKLTRLLYERFCHFDGAADKGWVLLPCELIDYNGVAL
KELVLRYAAQWKLTPTFTAWLNDHNTFCSTLVDRIVTGYPRAEVEALEQEMGYKDTFWDT
AEHFYLFVIQGPQWLAEELRLNKLDLNVRIVDDIKPYKERKVAILNGAHTALVPVAFLAG
LDTVGESMNDALIGKFVEKTIAEEIVPVLDLPNDELTSFAQAVLSRFRNPFIQHQLLSIS
LNGMTKFRTRILPQLLTYRERHGELPARLTFALAALIAFYRGERGGEGDALQTYPLQDDA
HWLERYSTLWAGVKENTVSLAELVNVVLRDADHWEQDLTQVPGLAAQVTEQLQTIVERGM
RAAVEGYC