Protein Info for HER17_RS18275 in Pectobacterium carotovorum WPP14

Annotation: type I polyketide synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00109: ketoacyl-synt
  • amino acids 10 to 259 (250 residues), 226.7 bits, E=1.5e-70
• PF02801: Ketoacyl-synt_C
  • amino acids 267 to 386 (120 residues), 127.3 bits, 1.3e-40
• PF16197: KAsynt_C_assoc
  • amino acids 388 to 492 (105 residues), 44.6 bits, 7.1e-15
• PF00698: Acyl_transf_1
  • amino acids 531 to 829 (299 residues), 188 bits, E=1.3e-58
• PF21394: Beta-ketacyl_N
  • amino acids 957 to 1109 (153 residues), 45.2 bits, E=3.3e-15
• PF08659: KR
  • amino acids 1161 to 1353 (193 residues), 151.1 bits, E=1.3e-47
• PF14765: PS-DH
  • amino acids 1538 to 1656 (119 residues), 39.9 bits, 1.4e-13
• PF00550: PP-binding
  • amino acids 1760 to 1823 (64 residues), 47.3 bits, see alignment (E = 7.9e-16)

Best Hits

KEGG orthology group: None (inferred from 96% identity to pct:PC1_0573)

Predicted SEED Role

"Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 2.3.1.39)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (51/53 steps found)
• superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
• superpathway of fatty acid biosynthesis I (E. coli) (16/16 steps found)
• superpathway of fatty acid biosynthesis initiation (5/5 steps found)
• fatty acid biosynthesis initiation (type II) (3/3 steps found)
• fatty acid biosynthesis initiation (mitochondria) (3/4 steps found)
• fatty acid biosynthesis initiation (plant mitochondria) (1/4 steps found)
• mycobactin biosynthesis (2/11 steps found)
• pederin biosynthesis (2/14 steps found)
• bryostatin biosynthesis (2/19 steps found)
• mupirocin biosynthesis (2/26 steps found)
• corallopyronin A biosynthesis (2/30 steps found)

KEGG Metabolic Maps

• Fatty acid biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.39

Use Curated BLAST to search for 2.3.1.39

Protein Sequence (1833 amino acids)

>HER17_RS18275 type I polyketide synthase (Pectobacterium carotovorum WPP14)
MKQQEQFRDKDIAIVGMSARFPGAEDTAIFWQNLLDGVETISTFSEEELRESGIEEEMIA
SPNYIRRRGILGNAQHFDANFFDITPRDAEIMDPQHRVFLECCWHAFEDAGYVPATYPGK
VGIFGGTGTAWHLSKVNAHPEVQKYASGASVVTNNDKDYVTTRVSYKLNLKGPSVNVQTA
CSTAMVAVVMGMNSLLNGESDLIVAGGVSVDTPERRGYPYMQGGMESADGRCYAFDSRAN
GTVFSRGAGVVLLKRLNDAVRDGDHIYAVLKGGAVNNDGNLKAGFTAPSIHGQIAVAKQA
IANAQLDPATINFVEAHGTATALGDPIEFTSLTQTFQEYTDKTQYCRLGSVKTNIGHTDA
ASGMASLIKASLALETGKLPASLHFESPNPNIEFETSPFIMNTELSELEPSETPHRALVN
SFGVGGTNACVILEAAPSLKAGDIHDNSLLVLPFSAKSRTALEDMKRRLRDYLSAHDDAN
LADIAYTLQVGRQKFSHSTAIIGKDRDSLLAKLDQPSLVVTQQGKNQKSVVFMFPGQGNQ
YVNMARELYDTYDVFRASMDQCCNYLEPILDVNLTSIIFQDSDNIAESRINETQFTQPSL
FVVEYSLAKLWMSWGIQPDVMIGHSVGEYVAACLSGVFSLEDALKAVAMRGKMVQALPAG
DMLAVLLDEESLKAKLHGSKLEIAAVNYPGLCVIAGASNDVARFQQQLEDSNIFCKHLDT
SHAFHSHMMEPMLPAFKKVIDSITLHAPQIPFVSTVNGEWVTEELAKNSDYWVRHVRNPV
LFSHAFKTLMADEHHDFVFLEVGPGRSLESSAKQHFSAEDGALIYASLPTAKDVALSGEH
LLSTLGALWASGVNVPWHQHHPEQHRRRIPLPGYPFERKRFALPTLSSASNDMQSEQSVK
AKKRKQADIGDWFYMPTWKKTIPAKYMAGKRVEAENTCWLLLTDTLGIAERAKQLLEKDG
HKVFFVSPGTQYQEALSEGQYTLNVSSRADYVRLLKSLTEQGLRPSRILYLWNLTVAEQV
QPLEHTYLSSPLNTFYPALYLQQALVNENLLDDLHVTFATSNTFSVMGERIASPENALLV
GPSRVFYHEYPEVQCHLVDIDLKQNAEQLDEFAHSLIAESHIATHGNLVAYRGNQRWEES
YQAVHLKQDDLGLPAELKDDGVYLITGGLGGLGILLANHLSENSNATIILTYRAALPPRE
EWQAWIQQHPVDDPISEKLASVLRLEARGNTIHLAQVDVNDYHGMREMLSAFPQVDGVFH
TAGVAGGGIIALKNDADCANVLDPKVAGSLILDELLQDKQPDFFILFSSITSIVGDEARI
DYCSGNAFMDAFAHYRNQHRRGRTVSLNWGKWGDVGMAVRWGKQLQEKKNSKLAAVEEAK
GDLLTLLDREGMQESYQVNLTTKDWVIDEHRLAKQPSLVGATILSLLHEFMTGFKSQESL
QVKNLMLTKPVIYTDAWPRQMRLFITPEGKGYKFSLKTQGVLELAWQEHAFGSIGHGAPT
ADLAPQSIDAIKQRCTTQVPYAPFITELGNANTGENFLSFSQRWNNHREIAQGHNEWLIH
KVLGSDYTHDLTRYPYHPAVIDATAISCLSLITQENFLPISYGKMTFLSPLGKECYAHAR
LKQAYQPQDNAIVMDITFLSPEGIPLLVLENYTLLKMTMGNQLATSENASTAATAAVKVN
LADKDILLPEGLDAIKRQLAHLEFEQLVVVTSDLDQLIYESIPEQETPEFILQNSEATEG
YARPALSVDYVAPENDIEKEIVKVWQSILGISGIGVNDSFTELGGNSLLAVQVVSTVSGI
FEIDIRVDLFYQNQTVKGLATLILTELEALLQE