Protein Info for HER17_RS17985 in Pectobacterium carotovorum WPP14

Annotation: SDR family oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 249 PF00106: adh_short" amino acids 7 to 190 (184 residues), 153.4 bits, see alignment E=1.1e-48 PF01370: Epimerase" amino acids 9 to 154 (146 residues), 23 bits, see alignment E=9.5e-09 PF08659: KR" amino acids 10 to 165 (156 residues), 53.9 bits, see alignment E=4.4e-18 PF13561: adh_short_C2" amino acids 16 to 246 (231 residues), 200.8 bits, see alignment E=5.4e-63

Best Hits

Swiss-Prot: 35% identical to DHB14_BOVIN: 17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) from Bos taurus

KEGG orthology group: None (inferred from 95% identity to eca:ECA0747)

MetaCyc: 32% identical to fructuronate reductase (Thermotoga maritima)
1.1.1.-; 1.1.1.-

Predicted SEED Role

"Putative short chain oxidoreductase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (249 amino acids)

>HER17_RS17985 SDR family oxidoreductase (Pectobacterium carotovorum WPP14)
MKRLQDKFALITGGTSGIGIETARQFLAEGATVAITGRDEKALARAQAELGHSTLAIRCD
AGDIRAQYDLAQTLTQQWPRLDVLYANAGDVTHRPLEGWDESAWDRLMATNLKGPFFLVQ
ALLPLLNNPASVILCGSTSAHIGLPQSSAYAASKAGLLSLARTLSAELVTRGIRVNGLSP
GPTETPALDKLGLSPEQQSAMQEQIRQLVPIGRMGTPWELAKAAVFLASDESRFVVGTEL
LVDGGVANL