Protein Info for HER17_RS17275 in Pectobacterium carotovorum WPP14

Annotation: tryptophan permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 424 transmembrane" amino acids 21 to 44 (24 residues), see Phobius details amino acids 50 to 72 (23 residues), see Phobius details amino acids 98 to 117 (20 residues), see Phobius details amino acids 137 to 155 (19 residues), see Phobius details amino acids 164 to 185 (22 residues), see Phobius details amino acids 200 to 218 (19 residues), see Phobius details amino acids 238 to 256 (19 residues), see Phobius details amino acids 295 to 319 (25 residues), see Phobius details amino acids 331 to 350 (20 residues), see Phobius details amino acids 356 to 378 (23 residues), see Phobius details amino acids 397 to 416 (20 residues), see Phobius details PF03222: Trp_Tyr_perm" amino acids 21 to 412 (392 residues), 500.7 bits, see alignment E=1.7e-154 TIGR00837: aromatic amino acid transport protein" amino acids 25 to 405 (381 residues), 509.5 bits, see alignment E=3.6e-157

Best Hits

Swiss-Prot: 73% identical to MTR_ECOLI: Tryptophan-specific transport protein (mtr) from Escherichia coli (strain K12)

KEGG orthology group: K03835, tryptophan-specific transport protein (inferred from 96% identity to eca:ECA0872)

MetaCyc: 73% identical to tryptophan:H+ symporter Mtr (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-142; TRANS-RXN-76

Predicted SEED Role

"Tryptophan-specific transport protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (424 amino acids)

>HER17_RS17275 tryptophan permease (Pectobacterium carotovorum WPP14)
MATRAVNENTVEKSGTEKRLPSLFGGSMIIAGTIIGAGMFSLPVVMSGAWFFWSFAVLVF
TWFCMYHSGLMILEANLNYPTGASFDTLTKDLLGKTWNVINGISIAFVLYILTYAYISAS
GSIIHHTLAEMSIDFSARVGGCLFALFVALTVWWSTAAVSRMTAFFLAAKVLTFFMTFGS
LLWNVKPVVLLNVAEEAPSYLPYVLMTLPFCLASFGFHGNVPSLVKHYGHKPQVIKRCLF
IGSALALVMYAIWLIGTMGNIARPDFIGIAERGGNIDVLVQTLGSVLNSPYLDVLLTVFS
NFAVACSFLGVTLGLFDYLADLLKFDDSRLGRAKTALVTFLPPIIGGLLYPNGFIYAIGF
AGLAATVWAVITPALLALASRRRFGSPLFRVRGGNAMVALVLLFGIGTALIHVLSSLDLL
PVYR