Protein Info for HER17_RS17140 in Pectobacterium carotovorum WPP14

Annotation: SAM-dependent methyltransferase TehB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 286 PF09313: DUF1971" amino acids 8 to 88 (81 residues), 105.9 bits, see alignment E=3.4e-34 TIGR00477: tellurite resistance protein TehB" amino acids 48 to 285 (238 residues), 365.7 bits, see alignment E=4.3e-114 PF03848: TehB" amino acids 90 to 282 (193 residues), 334.2 bits, see alignment E=7.9e-104 PF05175: MTS" amino acids 114 to 190 (77 residues), 24.3 bits, see alignment E=8.6e-09 PF13489: Methyltransf_23" amino acids 117 to 218 (102 residues), 29.1 bits, see alignment E=3e-10 PF13847: Methyltransf_31" amino acids 121 to 222 (102 residues), 28.2 bits, see alignment E=5.8e-10 PF13649: Methyltransf_25" amino acids 124 to 217 (94 residues), 37.6 bits, see alignment E=1.2e-12 PF08241: Methyltransf_11" amino acids 124 to 218 (95 residues), 34.1 bits, see alignment E=1.4e-11

Best Hits

Swiss-Prot: 61% identical to TEHB_HAEI1: Probable S-adenosyl-L-methionine-dependent methyltransferase TehB (tehB) from Haemophilus influenzae (strain 10810)

KEGG orthology group: None (inferred from 97% identity to pct:PC1_0782)

Predicted SEED Role

"Tellurite resistance protein TehB"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (286 amino acids)

>HER17_RS17140 SAM-dependent methyltransferase TehB (Pectobacterium carotovorum WPP14)
MQDLICYKKMPQWNSQTLPAAFQEKHNTQEGTWAKLTVLKGEMTFSMLTEDGDTLETFQF
SEQNQPPFVEPQAWHRIVSFSDDLECQLSFFCSAEDFYHKKYGLTRTHSEVINAVQHIKP
GKTLDLGCGGGRNALYLNLRGFDVTACDKHEQSIDSLNNIIKSEALENIRAGVYNINLAE
IKEQYDFILSTVVLMFLERDRIPHIISNMQDSTVNGGYNLIIAAMSTEDCPCPMPFSFTF
KEGELKNYYADWEILKYNEDMGELHKTDAQGNRIKLRFATLLARKP