Protein Info for HER17_RS14075 in Pectobacterium carotovorum WPP14

Annotation: type I secretion system permease/ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 615 transmembrane" amino acids 24 to 47 (24 residues), see Phobius details amino acids 58 to 81 (24 residues), see Phobius details amino acids 145 to 176 (32 residues), see Phobius details amino acids 252 to 269 (18 residues), see Phobius details amino acids 274 to 284 (11 residues), see Phobius details TIGR01842: type I secretion system ATPase" amino acids 17 to 559 (543 residues), 770.7 bits, see alignment E=3.8e-236 PF00664: ABC_membrane" amino acids 27 to 283 (257 residues), 60.2 bits, see alignment E=2.6e-20 PF00005: ABC_tran" amino acids 350 to 497 (148 residues), 103.6 bits, see alignment E=1.5e-33

Best Hits

Swiss-Prot: 57% identical to APRD_PSEAE: Alkaline protease secretion ATP-binding protein AprD (aprD) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K12536, ATP-binding cassette, subfamily C, bacterial HasD (inferred from 94% identity to pct:PC1_1409)

Predicted SEED Role

"ABC exporter for hemopore HasA, ATP-binding component HasD" in subsystem Protein secretion by ABC-type exporters

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (615 amino acids)

>HER17_RS14075 type I secretion system permease/ATPase (Pectobacterium carotovorum WPP14)
MPASHPASSGREIIDALAAYRQGFWGIGLFSAVINLLMLAPAIYMLQVYDRVLPSSSTMT
LAMLTIIMLGLFLLMGLLEWIRSAVVIRLGTQMDMRLNQRIYNAAFESNLKNGTAGAGQA
LNDLTALRQFATGNALFAFFDAPWFPVYLLVIFLLHPWLGVMALAGAIILIVLAWLNQQL
TREPLALAAQNTVQATQQANANLRNADAIEAMGMLPAMRERWLTQHKSFLYYQNVASEKS
ANITSLTKSTRLALQSLMLGLGALLAVKGDITPGMMIAGSILVGRVLSPIDQIIGVWKQW
MQARLAWQRVNLLLNNHPARPAGMALPAPEGKLQVEQLSANAPNTRTPILANITFELAPG
DVLGVLGPSGSGKSTLARLLVAAMPALGGKVRLDGADMHQWDKADLGRFVGYLPQDVQLF
SGTIAENIARFTQPDPEKIVSAAVTAGVHEMILRLPQGYDTLLGEGGAGLSGGQKQRVAL
ARTIYNQPRLIVMDEPNASLDDDGEKALLAAIAAQQEAKSTQVLITHKPALLSCANKLLV
LRAGQIQYFGATEQVLKELQRAKPAKAPIATPPSAKPAPVKTADAANAFIPKEPSSAGLS
MVYSAPASRRAAPDK