Protein Info for HER17_RS13650 in Pectobacterium carotovorum WPP14

Annotation: heavy metal response regulator transcription factor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 230 TIGR01387: heavy metal response regulator" amino acids 3 to 221 (219 residues), 297.8 bits, see alignment E=2.4e-93 PF00072: Response_reg" amino acids 4 to 112 (109 residues), 87.8 bits, see alignment E=5.5e-29 PF00486: Trans_reg_C" amino acids 146 to 221 (76 residues), 85 bits, see alignment E=3.2e-28

Best Hits

Swiss-Prot: 59% identical to COPR_PSEUB: Transcriptional activator protein CopR (copR) from Pseudomonas syringae pv. tomato

KEGG orthology group: K07665, two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR (inferred from 94% identity to ddc:Dd586_2641)

Predicted SEED Role

"DNA-binding heavy metal response regulator" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (230 amino acids)

>HER17_RS13650 heavy metal response regulator transcription factor (Pectobacterium carotovorum WPP14)
MRLLLVEDEEKTSSYIYRALSELGYTVDVAADGIDGLHLAVQYDYDAVILDVMLPGKDGY
AVLEGLRLHKQTPVLMLSARGSVDERVKGLRHGADDYLSKPFSLIELVARIQALLRRRLS
DGVDVTQLHIDDMHLDLLARRVTRAGQRLDLTAKEFALLSLLARHQGEILSKMMIAEQVW
DMNFDSDANVVEVAVKRLRAKVDAPYTVKLLHTVRGMGYVLENRPAPRLE