Protein Info for HER17_RS12530 in Pectobacterium carotovorum WPP14

Annotation: aspartate:alanine antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 562 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 37 to 55 (19 residues), see Phobius details amino acids 61 to 85 (25 residues), see Phobius details amino acids 92 to 118 (27 residues), see Phobius details amino acids 160 to 181 (22 residues), see Phobius details amino acids 382 to 401 (20 residues), see Phobius details amino acids 407 to 426 (20 residues), see Phobius details amino acids 447 to 465 (19 residues), see Phobius details amino acids 475 to 498 (24 residues), see Phobius details amino acids 533 to 557 (25 residues), see Phobius details PF06826: Asp-Al_Ex" amino acids 17 to 181 (165 residues), 124.3 bits, see alignment E=4.7e-40 amino acids 385 to 554 (170 residues), 149.6 bits, see alignment E=7.6e-48 TIGR01625: AspT/YidE/YbjL antiporter duplication domain" amino acids 21 to 168 (148 residues), 120.9 bits, see alignment E=2.1e-39 amino acids 390 to 541 (152 residues), 150.1 bits, see alignment E=2.2e-48 PF02080: TrkA_C" amino acids 227 to 285 (59 residues), 36.3 bits, see alignment 4.2e-13 amino acids 304 to 371 (68 residues), 36.9 bits, see alignment E=2.6e-13

Best Hits

Swiss-Prot: 98% identical to Y2683_PECAS: Putative transport protein ECA2683 (ECA2683) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K07085, putative transport protein (inferred from 98% identity to pct:PC1_1686)

Predicted SEED Role

"TrkA, Potassium channel-family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (562 amino acids)

>HER17_RS12530 aspartate:alanine antiporter (Pectobacterium carotovorum WPP14)
MNINVADLLNGNYILLLFVVLSLGLCLGKLRLGPVQLGNSIGVLVVSLLLGQQHFSINTE
ALSLGFMLFIFCVGVEAGPNFFSIFFRDGKNYFMLALVMVGSAMLLALGLGKFFGWGIGL
TAGMLAGSMTSTPVLVGAGDTLRNTASLGNQLGIEQDHLSLGYALTYLVGLVSLIFGARY
LPKLQHQDLPTSAQQIARERGLDPDSQRKVYLPVIRAYRVGPELVDWADGKNLRELGIYR
QTGCYIERIRRNGILANPDGDAVLQIGDEIALVGYPDAHSRLNSNFRDGKEVFDRDLLDM
RIVTEEIVVKNHNAVGKRLSQLKLTDHGCFLNRIVRSQIEMPIDDNVVLNKGDVLQVSGD
ARRVKSIADRIGFISIHSQVTDLLAFCAFFVIGVMVGLITIQFSNFTFGIGNAAGLLFAG
IMLGFLRANHPTFGYIPQGALNMVKEFGLMVFMAGVGLSAGSTINSSLGEVGIQMLASGL
IVSLLPVVICFLFGAYVLKMNRALLFGAMMGARTCAPAMEIISDTARSNIPALGYAGTYA
IANVLLTLAGSLIVVIWPELPG