Protein Info for HER17_RS11525 in Pectobacterium carotovorum WPP14

Annotation: amino acid permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 466 transmembrane" amino acids 26 to 44 (19 residues), see Phobius details amino acids 50 to 69 (20 residues), see Phobius details amino acids 105 to 128 (24 residues), see Phobius details amino acids 134 to 152 (19 residues), see Phobius details amino acids 161 to 182 (22 residues), see Phobius details amino acids 205 to 227 (23 residues), see Phobius details amino acids 247 to 269 (23 residues), see Phobius details amino acids 289 to 307 (19 residues), see Phobius details amino acids 338 to 360 (23 residues), see Phobius details amino acids 367 to 386 (20 residues), see Phobius details amino acids 407 to 428 (22 residues), see Phobius details amino acids 434 to 452 (19 residues), see Phobius details PF00324: AA_permease" amino acids 25 to 459 (435 residues), 424.9 bits, see alignment E=3.9e-131 PF13520: AA_permease_2" amino acids 29 to 443 (415 residues), 107.1 bits, see alignment E=1.1e-34

Best Hits

Swiss-Prot: 70% identical to AROP_ECOLI: Aromatic amino acid transport protein AroP (aroP) from Escherichia coli (strain K12)

KEGG orthology group: K03293, amino acid transporter, AAT family (inferred from 98% identity to pct:PC1_1887)

MetaCyc: 70% identical to aromatic amino acid:H+ symporter AroP (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-56; TRANS-RXN-76; TRANS-RXN-77

Predicted SEED Role

"Aromatic amino acid transport protein AroP" in subsystem Aromatic amino acid degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (466 amino acids)

>HER17_RS11525 amino acid permease (Pectobacterium carotovorum WPP14)
MANAQNNIATDQQELVLKRGLKNRHIQLIALGGAIGTGLFLGISQTIQMAGPSVLLGYAI
AGMIAFLIMRQLGEMVVEEPVAGSFSHFAYKYWGDFAGFLAGWNYWAMFILVGMAELTAV
GIYIQYWWPETPTWLSAAIFFVLINLINLVNVRMFGETEFWFALIKVLAIVGMIVFGSWL
LLSGNGGETATVRNLWIHGGFMPNGASGLIMAMAVIMFSFGGLELVGITAAEAADPKRSI
PQATNQVVYRILIFYIGALSILLSLYPWGKVVDGGSPFVLIFQALNSNIVANVLNIVVLT
AALSVYNSGVYCNSRMLYGLAKQGNAPKSLAKVNARGVPVRSIVLSALATSFGVAINYLM
PGKAFELLMALVVSTLVINWIMICFAHLRFRQAMIEKGIVPAFKAFWYPWGNYLCLAFLA
GILVIMLLSPGIRISVILIPFWIAVIWFGFRFSRKNNAALKSVQTP