Protein Info for HER17_RS11035 in Pectobacterium carotovorum WPP14

Annotation: thymidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00265: TK
  • amino acids 2 to 186 (185 residues), 198 bits, E=5.8e-63

Best Hits

Swiss-Prot: 98% identical to KITH_PECAS: Thymidine kinase (tdk) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K00857, thymidine kinase [EC: 2.7.1.21] (inferred from 99% identity to pwa:Pecwa_2283)

MetaCyc: 78% identical to thymidine/deoxyuridine kinase (Escherichia coli K-12 substr. MG1655)
Deoxynucleoside kinase. [EC: 2.7.1.145, 2.7.1.21]; 2.7.1.145,2.7.1.21 [EC: 2.7.1.145, 2.7.1.21]

Predicted SEED Role

"Thymidine kinase (EC 2.7.1.21)" in subsystem Folate Biosynthesis (EC 2.7.1.21)

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleoside salvage (8/9 steps found)
• pyrimidine deoxyribonucleosides salvage (4/5 steps found)
• purine deoxyribonucleosides salvage (4/6 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.145 or 2.7.1.21

Protein Sequence (198 amino acids)

>HER17_RS11035 thymidine kinase (Pectobacterium carotovorum WPP14)
MAQLYFYYSAMNAGKSTALLQSSYNYQERGMRTLVFTAEIDNRHGVGIVSSRIGLSSPAL
LFNPQTSLFGLLEKEHRAQPVDCVLIDECQFLTREQVSELSDVVDQLDIPVLCYGLRTDF
RGDLFSGSHYLLAWADKLIELKTVCHCGRKANCVLRLDAQGNAVHEGEQVVIGGNESYVS
VCRKHYKIALGLTRKESE