Protein Info for HER17_RS09575 in Pectobacterium carotovorum WPP14

Annotation: transcriptional regulator TyrR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 522 PF01842: ACT" amino acids 3 to 62 (60 residues), 30.8 bits, see alignment E=5.9e-11 PF00158: Sigma54_activat" amino acids 206 to 371 (166 residues), 213.3 bits, see alignment E=5.5e-67 PF14532: Sigma54_activ_2" amino acids 208 to 376 (169 residues), 64.7 bits, see alignment E=3.3e-21 PF18024: HTH_50" amino acids 464 to 512 (49 residues), 64.3 bits, see alignment 1.9e-21 TIGR04381: TyrR family helix-turn-helix domain" amino acids 465 to 512 (48 residues), 95.6 bits, see alignment 6.6e-32

Best Hits

Swiss-Prot: 71% identical to TYRR_ENTAG: Transcriptional regulatory protein TyrR (tyrR) from Enterobacter agglomerans

KEGG orthology group: K03721, transcriptional regulator of aroF, aroG, tyrA and aromatic amino acid transport (inferred from 97% identity to pwa:Pecwa_2604)

Predicted SEED Role

"Transcriptional repressor protein TyrR" in subsystem Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) or Phenylalanine and Tyrosine Branches from Chorismate

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (522 amino acids)

>HER17_RS09575 transcriptional regulator TyrR (Pectobacterium carotovorum WPP14)
MHLEVICEDRIGMVRELLDLLASRNIDLRGIEIASIGRIYLNFATLDFDDFRLLMTEIRR
IESVSDVRTVAFMPSEREHRALNALLESMPEPVFSLDMKGKLELFNPAALALFEQSAETI
SELTIGSMIPGFNFASWLEKSSAVVAERVVLRGQDFLLEMTPVRLEDDAGKVATAGALVM
LKSAARMGRQLQNLAVNDENEFDHIVAVSPKMRQVVEQARKLAMLDAPLLIVGDTGTGKD
MLARACHLRGPRGKNPFLALNCAALPDDVMESELFGHAPGAYLNAQEGKKGFFEQANGGS
VLLDEVGEMSAQMQTKLLRFLNDGTFRRVGEDHEVHVDVRVICATKKNLLELVQRGEFRE
DLYYRLNVLTLMLPPLRERPADIMPLAELFVARFADEQGISRPKLAADVEHFLPQYGWPG
NVRQLRNTIYRALTQLEGNELHMQDIDLPAFSIDAPQDETLLDGSLDDINKRFERSVLTR
LYQSYPSTRKLAKRLGVSHTAIANKLREYGLSQRKAAGDDEE