Protein Info for HER17_RS09250 in Pectobacterium carotovorum WPP14

Annotation: Grx4 family monothiol glutaredoxin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 116 TIGR00365: monothiol glutaredoxin, Grx4 family" amino acids 6 to 102 (97 residues), 153.2 bits, see alignment E=8.6e-50 PF00462: Glutaredoxin" amino acids 18 to 82 (65 residues), 72.8 bits, see alignment E=1e-24

Best Hits

Swiss-Prot: 89% identical to GLRX4_SHIFL: Glutaredoxin 4 (grxD) from Shigella flexneri

KEGG orthology group: K07390, monothiol glutaredoxin (inferred from 97% identity to pwa:Pecwa_2670)

Predicted SEED Role

"Glutaredoxin-related protein" in subsystem Glutaredoxins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (116 amino acids)

>HER17_RS09250 Grx4 family monothiol glutaredoxin (Pectobacterium carotovorum WPP14)
MTTPTIEKIQRQIAENPILLYMKGSPKLPSCGFSAQTVQALSACGERFAYVDILQNPDIR
AELPKYANWPTFPQLWVDGELIGGCDIVVEMFQRGELQPLIKETADKYKAQQADQE