Protein Info for HER17_RS09040 in Pectobacterium carotovorum WPP14

Annotation: heme ABC transporter permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 246 transmembrane" amino acids 21 to 44 (24 residues), see Phobius details amino acids 58 to 81 (24 residues), see Phobius details amino acids 91 to 113 (23 residues), see Phobius details amino acids 129 to 149 (21 residues), see Phobius details amino acids 158 to 180 (23 residues), see Phobius details amino acids 200 to 221 (22 residues), see Phobius details PF01578: Cytochrom_C_asm" amino acids 8 to 184 (177 residues), 147.5 bits, see alignment E=2.2e-47 TIGR01191: heme exporter protein CcmC" amino acids 45 to 225 (181 residues), 264 bits, see alignment E=3.8e-83

Best Hits

Swiss-Prot: 71% identical to CCMC_SHIFL: Heme exporter protein C (ccmC) from Shigella flexneri

KEGG orthology group: K02195, heme exporter protein C (inferred from 97% identity to pwa:Pecwa_2726)

MetaCyc: 71% identical to cytochrome c maturation protein C (Escherichia coli K-12 substr. MG1655)
RXN-21407

Predicted SEED Role

"Cytochrome c-type biogenesis protein CcmC, putative heme lyase for CcmE" in subsystem Biogenesis of c-type cytochromes

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (246 amino acids)

>HER17_RS09040 heme ABC transporter permease (Pectobacterium carotovorum WPP14)
MLKKNYQLTQPDRLYGLCGRLIPWVALISATLLIGGCLLGFGFAPADYQQGQGYRIMYLH
VPAAVWSMGVYAVMAIFALIGMIRQSKTAELAVAAMAPVGAVFTFIALTTGATWGKPMWG
TWWVWDARLTSELVLLFLYVGIIALYNAFDDRRLAGRAAAILVLVGVVNLPIIHFSVEWW
NTLHQGSTKMQKTIDPAMRLPLRIMMLGFMSLFVTLSLMRLRNLILVQQRRAPWVAALLN
KGGIAR