Protein Info for HER17_RS07410 in Pectobacterium carotovorum WPP14

Annotation: pyridoxal-phosphate dependent enzyme

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00291: PALP
  • amino acids 8 to 301 (294 residues), 258.6 bits, E=8.2e-81
• PF00571: CBS
  • amino acids 344 to 388 (45 residues), 36 bits, 7.4e-13
  • amino acids 400 to 448 (49 residues), 27 bits, 4.6e-10

Best Hits

KEGG orthology group: K01697, cystathionine beta-synthase [EC: 4.2.1.22] (inferred from 82% identity to ddc:Dd586_1871)

Predicted SEED Role

"Cystathionine beta-synthase (EC 4.2.1.22)" in subsystem Cysteine Biosynthesis or Glycine and Serine Utilization or Methionine Biosynthesis or Methionine Degradation (EC 4.2.1.22)

MetaCyc Pathways

• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (10/10 steps found)
• superpathway of L-cysteine biosynthesis (fungi) (6/6 steps found)
• homocysteine and cysteine interconversion (4/4 steps found)
• L-cysteine biosynthesis III (from L-homocysteine) (2/2 steps found)
• hydrogen sulfide biosynthesis II (mammalian) (4/6 steps found)
• superpathway of L-cysteine biosynthesis (mammalian) (3/5 steps found)
• taurine biosynthesis III (1/3 steps found)
• superpathway of L-methionine salvage and degradation (7/16 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Methionine metabolism
• Selenoamino acid metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.22

Use Curated BLAST to search for 4.2.1.22

Protein Sequence (455 amino acids)

>HER17_RS07410 pyridoxal-phosphate dependent enzyme (Pectobacterium carotovorum WPP14)
MKSANAVLDLIGHTPLLELTQFDTGPCRLFVKLENQNPGGSIKDRVALSMIENAERQGWL
KPGGTIVEATAGNTGLGLALVAALKGYHLILVVPDKMSREKIFHLRALGAEVRLTRSDVA
KGHPDYYQDYARRLAEETPDAYYIDQFNNPANLEAHYRTTGPELWQQMEEQIDAVAVGVG
SGGTLGGLTRYFAEVSPQTAFVLADPAGSILTDYLQRGEYGEAGSWLVEGIGEDFVPALA
DFTQVTHAYAIDDAESFHTARELLRKEGVLAGSSSGTLLAAALRYCRAQTEPKRVVTFVC
DSGNKYLSKMFNDYWMIEKGLITRPSHGDLRDLITYRHDEGATVSVSPDDTLSVVHARMR
LYDISQLPVLDNDRVVGVIDEWDLLNSLKNDTQHFSLTAREAMSDQVKTLPKEASPNDLL
AIFDRGFVAVILDGDRFLGLITRTDVLNHWRQTLR