Protein Info for HER17_RS06390 in Pectobacterium carotovorum WPP14

Annotation: galactokinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 387 TIGR00131: galactokinase" amino acids 11 to 385 (375 residues), 438.5 bits, see alignment E=1e-135 PF10509: GalKase_gal_bdg" amino acids 14 to 61 (48 residues), 74.4 bits, see alignment 6.2e-25 PF00288: GHMP_kinases_N" amino acids 118 to 185 (68 residues), 54.4 bits, see alignment E=2e-18 PF08544: GHMP_kinases_C" amino acids 283 to 364 (82 residues), 36.6 bits, see alignment E=7.2e-13

Best Hits

Swiss-Prot: 65% identical to GAL1_VIBCB: Galactokinase (galK) from Vibrio campbellii (strain ATCC BAA-1116 / BB120)

KEGG orthology group: K00849, galactokinase [EC: 2.7.1.6] (inferred from 96% identity to pct:PC1_2952)

MetaCyc: 60% identical to galactokinase (Escherichia coli K-12 substr. MG1655)
Galactokinase. [EC: 2.7.1.6]

Predicted SEED Role

"Galactokinase (EC 2.7.1.6)" in subsystem Lactose and Galactose Uptake and Utilization (EC 2.7.1.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (387 amino acids)

>HER17_RS06390 galactokinase (Pectobacterium carotovorum WPP14)
MSRIDSLRQLTESVFVRLFGYAPHAAIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVVSA
AVRQDGIVRVVAVDFDNQQDEFDLAKEIVPHPDYTWANYIRGTVKFLQARGLPLTGMDMV
VSGNVPSGAGLSSSASLEVAIGQTFKELNNLDISQLDVALNGQQAENDFVGCSCGIMDQF
ISAQGRVGQALLIDCRSLEGRSVRMLDGVDVLIVNSNVRRGLVDSEYNTRRQQCEAAARH
FNVKALRDVSLAQFEAGIEGLDPVAVRRARHVITENRRTLEAADALARQDAHRLFTLMAE
SHVSMRDDFEITVPPIDALVDLIQEYVGERGGVRMTGGGFGGCIVALIPSALTDEVKQVI
EREYPARTGLQPSIYLCQASGGAGRVS