Protein Info for HER17_RS04420 in Pectobacterium carotovorum WPP14

Annotation: MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 426 transmembrane" amino acids 30 to 47 (18 residues), see Phobius details amino acids 58 to 79 (22 residues), see Phobius details amino acids 90 to 110 (21 residues), see Phobius details amino acids 116 to 136 (21 residues), see Phobius details amino acids 157 to 177 (21 residues), see Phobius details amino acids 189 to 208 (20 residues), see Phobius details amino acids 238 to 257 (20 residues), see Phobius details amino acids 276 to 294 (19 residues), see Phobius details amino acids 306 to 325 (20 residues), see Phobius details amino acids 331 to 354 (24 residues), see Phobius details amino acids 365 to 387 (23 residues), see Phobius details amino acids 399 to 417 (19 residues), see Phobius details PF00083: Sugar_tr" amino acids 20 to 215 (196 residues), 92.7 bits, see alignment E=5.1e-30 amino acids 217 to 413 (197 residues), 35.9 bits, see alignment E=8.5e-13 TIGR00883: MFS transporter, metabolite:H+ symporter (MHS) family protein" amino acids 24 to 411 (388 residues), 471.5 bits, see alignment E=1.2e-145 PF07690: MFS_1" amino acids 57 to 377 (321 residues), 101.9 bits, see alignment E=7.5e-33 amino acids 277 to 416 (140 residues), 37.3 bits, see alignment E=3.3e-13

Best Hits

Swiss-Prot: 83% identical to KGTP_ECOLI: Alpha-ketoglutarate permease (kgtP) from Escherichia coli (strain K12)

KEGG orthology group: K03761, MFS transporter, MHS family, alpha-ketoglutarate permease (inferred from 98% identity to eca:ECA3522)

MetaCyc: 83% identical to alpha-ketoglutarate:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-23

Predicted SEED Role

"Alpha-ketoglutarate permease"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (426 amino acids)

>HER17_RS04420 MFS transporter (Pectobacterium carotovorum WPP14)
MTDLTENAKDTRQRIRAIVGASSGNLVEWFDFYVYSFCSIYFAHIFFPSGNTTTQLLQTA
GVFAAGFLMRPIGGWLFGYIADKHGRKNSMLISVCMMCFGSLVIACLPGYETIGTWAPFL
LLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVILQQI
LSDEDLRAWGWRIPFALGAILAIVALYLRRSLNETSDKTTRGHKDAGSLAGLWKHRRAFI
TVLGFTAGGSLAFYTFTTYMQKYLVNTAGMDAKTASGLMTLALFIFMLLQPFFGAMSDKI
GRRSSMLCFGGLAALLTVPILMVLQSVTSPVIAFSLVMLSLIIVSFYTSISGILKAEMFP
PEVRALGVGLSYAVANALFGGSAEYVALSLKSFGMETAFFWYVSVMGAIAFIVSLTLHRR
GKGMKL