Protein Info for HER17_RS03105 in Pectobacterium carotovorum WPP14

Annotation: catabolite repressor/activator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 334 TIGR02417: D-fructose-responsive transcription factor" amino acids 2 to 328 (327 residues), 474.7 bits, see alignment E=8e-147 PF00356: LacI" amino acids 3 to 50 (48 residues), 65.4 bits, see alignment 6.3e-22 PF00532: Peripla_BP_1" amino acids 62 to 303 (242 residues), 54.6 bits, see alignment E=2.5e-18 PF13407: Peripla_BP_4" amino acids 64 to 306 (243 residues), 39.5 bits, see alignment E=9.8e-14 PF13377: Peripla_BP_3" amino acids 180 to 330 (151 residues), 42.6 bits, see alignment E=1.4e-14

Best Hits

Swiss-Prot: 86% identical to CRA_SALTY: Catabolite repressor/activator (cra) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03435, LacI family transcriptional regulator, fructose operon transcriptional repressor (inferred from 98% identity to pwa:Pecwa_3791)

Predicted SEED Role

"Fructose repressor FruR, LacI family" in subsystem Fructose utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (334 amino acids)

>HER17_RS03105 catabolite repressor/activator (Pectobacterium carotovorum WPP14)
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGR
TRSIGLVIPDLENTSYTRIANYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDA
IIVSTALPPEHPFYQRWINGSLPIIALDRALDREHFTSVVGADLEDAEMLAQELRKVPAK
SVLYLGALPELSVSFLREQGFRQAWAGDPREVNYLYSNSYERVASAAAFMDYLKDNPMPE
ALFTTSFPLLQGVMDVNLKINGRLPNNLAIATFGDNELLDYLECPVLSVAQRHREVAERV
LELVLASLDEPKRPKPGLNRIRRNLYRRGSLSRA