Protein Info for HER17_RS02750 in Pectobacterium carotovorum WPP14

Annotation: murein transglycosylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 644 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details PF14718: SLT_L" amino acids 405 to 471 (67 residues), 85.9 bits, see alignment E=1.7e-28 PF01464: SLT" amino acids 483 to 593 (111 residues), 117.9 bits, see alignment E=1.8e-38

Best Hits

Swiss-Prot: 61% identical to SLT_SALTY: Soluble lytic murein transglycosylase (slt) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K08309, soluble lytic murein transglycosylase [EC: 3.2.1.-] (inferred from 96% identity to eca:ECA3900)

MetaCyc: 60% identical to soluble lytic murein transglycosylase (Escherichia coli K-12 substr. MG1655)
4.2.2.f [EC: 4.2.2.f]; 4.2.2.f [EC: 4.2.2.f]

Predicted SEED Role

"Soluble lytic murein transglycosylase precursor (EC 3.2.1.-)" (EC 3.2.1.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.-

Use Curated BLAST to search for 3.2.1.- or 4.2.2.f

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (644 amino acids)

>HER17_RS02750 murein transglycosylase (Pectobacterium carotovorum WPP14)
MQVIKAGHWWYAVSAICLAGFSGHVLADSLDEQRQRYQQVKQAWDSNQMDTVAQLMPTLR
SYPLYPYLEYRSLTQDLSQVSATQVKQFMATHPTLPPARNLSTSFVNELARRQDWIGLLA
FSPQPPKPVSARCNFYYAQWATGQRQGVWEATRDIWLTGRSLPTVCDKLFSVWQQAGEQT
PLTTLERARLAMDEGSGSLVSYLIKQLPDDYKTMGDALLKLQNDPNSLESFARTVGPTDF
TRKVTLSAFTRTARQDADNARSMLPVIVRLQKMSAAERQAMEETIAWRLMGNDATPEQAQ
WRDDVVRKSTSTTLLERRVRMALGAGDRQGLTSWMARLPAEALQKDEWRYWRAAALLDQG
KRQEGETLLRSLIQERGFYPMAAAQKLNERYPITIMTAVKPDPSLSQLPEITRVRELMFW
QMDNLARSEWVGLVANRSKPQQEALARYAFEQRWADLSVQATIVAKLWDHLEERFPLAWN
DEFRRETQGKGISQSYAMAIARQESAWNPKARSPVGASGLMQLMPATAQHTAKMSNITFY
TNTSQLFDPETNILLGTSYLEYVYQTFGRNRILSSAAYNAGPSRVNTWLKNSAGRIDPVA
FIESIPFSETRGYVKNVLAYDVFYRYFLNQPASVLTDAEWQRRY