Protein Info for HER17_RS00050 in Pectobacterium carotovorum WPP14

Annotation: PTS sugar transporter subunit IIC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 437 transmembrane" amino acids 35 to 53 (19 residues), see Phobius details amino acids 82 to 104 (23 residues), see Phobius details amino acids 111 to 130 (20 residues), see Phobius details amino acids 142 to 161 (20 residues), see Phobius details amino acids 182 to 201 (20 residues), see Phobius details amino acids 208 to 228 (21 residues), see Phobius details amino acids 230 to 260 (31 residues), see Phobius details amino acids 285 to 306 (22 residues), see Phobius details amino acids 343 to 363 (21 residues), see Phobius details amino acids 393 to 413 (21 residues), see Phobius details TIGR00410: PTS system, lactose/cellobiose family IIC component" amino acids 17 to 425 (409 residues), 375.2 bits, see alignment E=2.3e-116 PF02378: PTS_EIIC" amino acids 34 to 352 (319 residues), 198.3 bits, see alignment E=8.5e-63

Best Hits

KEGG orthology group: K02761, PTS system, cellobiose-specific IIC component (inferred from 98% identity to pwa:Pecwa_0009)

Predicted SEED Role

"PTS system, cellobiose-specific IIC component (EC 2.7.1.69)" in subsystem Beta-Glucoside Metabolism (EC 2.7.1.69)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (437 amino acids)

>HER17_RS00050 PTS sugar transporter subunit IIC (Pectobacterium carotovorum WPP14)
MSKLSESLFSVIENRISPIAAKLSSQRHVVAIKDGFIASMPFLIVGSFMMLFAHPPFSPN
SEWAFAQWWLGMVERHGEQIMMPYNMTMGIMAVYITSAIAYNLAQSYKMNGFMAASLALM
SFMVVAAPQIDKSLPVGSLGGEGIFTAIIVAIYSTELMHFLQKRNIGIRLPEQVPPKIRQ
SFDLLIPILAIFLTLFPLSLFMQSQFGMLLPQAIMAVFAPIISASDSLPAILIAVLLCHL
LWFAGIHGAVIVGGILQAFWLTNLGINQEAFNAGAPITKIFIEPFWQFFITVGGSGATMG
LVFLYLRSRSAHLRSIGKLAVVPSMFNINEPVIFGSPVVMNPLLFIPFITAPLVNATLAY
IALKTDLVHRVISLAPWTTPGPIGAAWSTGWDWRAVVLVGVLIVVSSLIYYPFFKMYERQ
LVAQEVGTAEEAVSDAR